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- W3029426810 abstract "Objective To evaluate the effects of different doses of dexmedetomidine compounded propofol and fentanil on hymodynamics and intraoperative somatosensory evoked potentials (SEPs) and motor evoked potentials (MEPs) monitoring on the senile people.Methods Forty-five patients undergoing selected anterior spinal fusion surgery were randomly divided into three groups by the dose of dexmedetomidine: group C (normal saline,NS); group D1 (dexmedetomidine injected by 0.3 μg·kg-1·h-1);group D2(dexmedetomidine injected by 0.8 μg·kg-1·h-1).The induction of all patients in three groups:midazolam 2 mg-3 mg,propofol Cp 1.5 mg/L (Marsh model),fentanil 1.5 μg/kg-2 μg/kg.When the patient's consciousness disappeared,a LMA was intubated and mechanical ventilation was made.In group D1 and group D2,dexmedetomidine (0.5 μg/kg over 10 min) was administered and then followed by an infusion of 0.3 μg·kg-1 ·h-1 or 0.8 μg ·kg-1 ·h-1 until the end of surgery.In group C,the same dose of NS instead of dexmedetomidine was administered.Anesthesia was maintained by target controlled injection of propofol.Bispectral index (BIS) were kept in the range of 45-55 by adjusting the concentration of propofol.Muscle relaxant wasn't be used in whole operation.SEPs and MEPs were monitored by a specialist during the operation.Results Heart rate were lower in group D1 and D2 than group C,but mean arterial pressure (MAP) were no different in three groups.The latency and the amplitude of SEPs P15-N20 were also no different in three groups (P＞0.05).Three patients's amplitudes of MEPs were disappeared in different degrees among the group D2.The positive rate is 3/15.There was a significant difference from the cases of group D1 (0/14) and C (0/14).After dexmedetomidine was stopped about 20 min-30 min,the amplitudes of MEPs recoveried in all the three patients.Conclusions In scnile paticnts,dexmedetomidine possibly prolonged analepsia time and decreased heart rate.Dexmedetomidine does not significantly influence the SEPs,but higher dose of dexmedetomidine depressed MEPs.Key words: Anesthesia, general; Senile; Anesthetics, intravenous; Evoked potentials; Medetomidine; Propofol" @default.
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- W3029426810 date "2012-11-15" @default.
- W3029426810 modified "2023-09-28" @default.
- W3029426810 title "Effects of propofol and fentanil compounded different doses of dexmedetomidine on hymodynamics and intraoperative somatosensory and motor evoked potentials monitoring of senile patient" @default.
- W3029426810 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2012.11.006" @default.
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