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- W3029441965 abstract "Objective To investigate the short-term efficacy of thymectomy and crisis risk factors in patients with myasthenia gravis (MG). Methods A retrospective review of 436 patients with myasthenia gravis treated by thymectomy was conducted, with statistical analysis on age, gender, duration of disease,clinical classification, pathology and pathological staging. Results Patients with clinical class Ⅰ disease were more stable in short-term symptoms (62.63%, 186/297), whereas those with clinical class Ⅱ A or above experienced more short-term improvement or deterioration (both P<0.05). Significant differences in gender,age, duration of disease, pathology, pathological staging and pathologic subgroups of thymoma were not identified (P>0.05). Logistic regression showed that incidence of post-surgical crisis was associated to thymoma (r=0.251, P<0.05) and clinical classification (r=1.300, P<0.05). The patients with thymoma or clinical classification over Ⅱ A had a higher chance for post-surgical crisis. Conclusions Instability in shortterm symptoms is more likely to occur in MG patients with clinical class Ⅱ A and above. Short-term efficacy is not associated with gender, age, duration of disease, pathologic types of thymus, pathological classification of thymoma, and pathologic types of thymoma. Patients with thymoma or clinical class Ⅱ A and above can be a high-risk population for post-surgical crisis, suggesting a need for thorough pre-surgical evaluation of risks and precaution during the perioperative period.Key words: Thymectomy; Myasthenia gravis; Thymic hyperplasia; Myasthenia gravis crisis; Thymoma" @default.
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- W3029441965 date "2010-06-15" @default.
- W3029441965 modified "2023-09-24" @default.
- W3029441965 title "Short-term efficacy of thymectomy and crisis risk factors in patients with myasthenia gravis" @default.
- W3029441965 doi "https://doi.org/10.3760/cma.j.issn.1674-1927.2010.03.007" @default.
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