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- W3029451569 abstract "ObjectiveTo evaluate the relationship between proportion of PR1 specific cytotoxic T lymphocytes (CTLs) in the peripheral blood and prognosis and curative effect in patients with HLA-A0201 positive chronic myelogenous leukemia (CML), and to discuss whether PR1 peptide could be used as the following immune therapeutic method for patients who had achieved the standard of stop treatment.MethodsThe soluble HLA-A0201/PR1 tetramer and flow cytometry were applied to determine the proportion and the frequency of PR1 specific CTLs in peripheral blood from 28 HLA-A0201 positive CML patients. The proportions were compared among different phases of patients. The correlations between the proportion of PR1 specific CTLs and clinical parameters were analyzed.ResultsThere was a negative correlation between PR1 specific CTLs and PCR (bcr-abl/abl)IS (r =-0.658, P 0.05). For patients treated with IM 400 mg qd, the frequency of PR1 specific CTLs in high-risk group was lower than that in low-risk or intermediate-risk groups.ConclusionPR1 specific CTLs can be detected in patients who achieved good curative effect, and is correlated with tumor burden, which indicates that PR1 specific CTLs may be related to the action of resisting leukemia and provide the evidence for PR1 peptide as a potential immune therapeutic schedule in patients who have achieved stable MR4.5 and MR5.0.Key words: Leukemia, myelogenous, chronic; PR1; Cytotoxic T lymphocytes; Tumor immunity" @default.
- W3029451569 created "2020-06-05" @default.
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- W3029451569 date "2015-08-25" @default.
- W3029451569 modified "2023-09-22" @default.
- W3029451569 title "Research on PR1 specific cytotoxic T lymphocytes of HLA-A0201 positive chronic myelogenous leukemia" @default.
- W3029451569 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2015.08.010" @default.
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