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• W3029458082 startingPage "1806" @default.
• W3029458082 abstract "Antiphospholipid syndrome (APS) or Hughes syndrome is an acquired thromboinflammatory disorder. Clinical criteria of APS diagnosis are large- and small-vessel thrombosis as well as obstetric problems; laboratory criteria are the presence of antiphospholipid antibodies (lupus anticoagulant, anticardiolipin antibodies and anti-β2-glycoprotein-1). The presence of at least 1 clinical and 1 laboratory criterion allows definitive diagnosis of APS. Primary APS is diagnosed in patients without features of connective tissue disease; secondary APS is diagnosed in patients with clinical signs of autoimmune disease. A high frequency of catastrophic APS as well as a high tendency to evolve from primary APS to secondary syndrome during the course of lupus and lupus-like disease is a feature of pediatric APS. The most characteristic clinical presentation of APS in the pediatric population is venous thrombosis, mainly in the lower limbs, and arterial thrombosis causing ischemic brain stroke. Currently, no diagnostic criteria for pediatric APS exist, which probably results in an underestimation of the problem. Similarly, no therapeutic procedures for APS specific for children have yet been established. In the present literature review, we discussed data concerning APS in children and its role in cerebrovascular diseases, including pediatric arterial ischemic stroke, migraine and cerebral venous thrombosis." @default.
• W3029458082 created "2020-06-05" @default.
• W3029458082 creator A5043460968 @default.
• W3029458082 creator A5085567030 @default.
• W3029458082 date "2020-05-26" @default.
• W3029458082 modified "2023-10-14" @default.
• W3029458082 title "Antiphospholipid syndrome and its role in pediatric cerebrovascular diseases: A literature review" @default.
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• W3029458082 doi "https://doi.org/10.12998/wjcc.v8.i10.1806" @default.
• W3029458082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7262698" @default.
• W3029458082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32518771" @default.
• W3029458082 hasPublicationYear "2020" @default.
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