Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029461577> ?p ?o ?g. }
- W3029461577 abstract "Background: The genetic predisposition to elite athletic performance has been a controversial subject due to the underpowered studies and the small effect size of identified genetic variants. The aims of this study were to investigate the association of common single-nucleotide polymorphisms (SNPs) with endurance athlete status in a large cohort of elite European athletes using GWAS approach, followed by replication studies in Russian and Japanese elite athletes and functional validation using metabolomics analysis. Results: The association of 476,728 SNPs of Illumina DrugCore Gene chip and endurance athlete status was investigated in 796 European international-level athletes (645 males, 151 females) by comparing allelic frequencies between athletes specialized in sports with high (n=662) and low/moderate (n=134) aerobic component. Replication of results was performed by comparing the frequencies of the most significant SNPs between 242 and 168 elite Russian high and low/moderate aerobic athletes, respectively, and between 60 elite Japanese endurance athletes and 406 controls. A meta-analysis has identified rs1052373 (GG homozygotes) in Myosin Binding Protein (MYBPC3; implicated in cardiac hypertrophic myopathy) gene to be associated with endurance athlete status (P=1.43E-08, odd ratio 2.2). Homozygotes carriers of rs1052373 G allele in Russian athletes had significantly greater VO2max than carriers of the AA+AG (P = 0.005). Subsequent metabolomics analysis revealed several amino acids and lipids associated with rs1052373 G allele (1.82x10-05) including the testosterone precursor androstenediol (3beta,17beta) disulfate. Conclusions: This is the first report of genome-wide significant SNP and related metabolites associated with elite athlete status. Further investigations of the functional relevance of the identified SNPs and metabolites in relation to enhanced athletic performance are warranted." @default.
- W3029461577 created "2020-06-05" @default.
- W3029461577 creator A5000294110 @default.
- W3029461577 creator A5015770154 @default.
- W3029461577 creator A5016052822 @default.
- W3029461577 creator A5018061261 @default.
- W3029461577 creator A5022147892 @default.
- W3029461577 creator A5022439983 @default.
- W3029461577 creator A5028292731 @default.
- W3029461577 creator A5029734133 @default.
- W3029461577 creator A5034424670 @default.
- W3029461577 creator A5047544416 @default.
- W3029461577 creator A5052691668 @default.
- W3029461577 creator A5056478743 @default.
- W3029461577 creator A5056816301 @default.
- W3029461577 creator A5058244878 @default.
- W3029461577 creator A5059983052 @default.
- W3029461577 creator A5061101327 @default.
- W3029461577 creator A5063224989 @default.
- W3029461577 creator A5063810474 @default.
- W3029461577 creator A5067928072 @default.
- W3029461577 creator A5075169564 @default.
- W3029461577 creator A5079820394 @default.
- W3029461577 creator A5080950140 @default.
- W3029461577 creator A5081842404 @default.
- W3029461577 creator A5081994437 @default.
- W3029461577 creator A5082136466 @default.
- W3029461577 creator A5091522881 @default.
- W3029461577 creator A5091795786 @default.
- W3029461577 date "2020-06-16" @default.
- W3029461577 modified "2023-10-12" @default.
- W3029461577 title "Genome-Wide Association Study Reveals a Novel Association Between MYBPC3 Gene Polymorphism, Endurance Athlete Status, Aerobic Capacity and Steroid Metabolism" @default.
- W3029461577 cites W1594030038 @default.
- W3029461577 cites W1613818593 @default.
- W3029461577 cites W1835373724 @default.
- W3029461577 cites W1966225853 @default.
- W3029461577 cites W1968697136 @default.
- W3029461577 cites W1973243569 @default.
- W3029461577 cites W1977539608 @default.
- W3029461577 cites W1980270094 @default.
- W3029461577 cites W1990807902 @default.
- W3029461577 cites W1991717798 @default.
- W3029461577 cites W1991869999 @default.
- W3029461577 cites W2004907725 @default.
- W3029461577 cites W2006417958 @default.
- W3029461577 cites W2012181254 @default.
- W3029461577 cites W2024679001 @default.
- W3029461577 cites W2035518059 @default.
- W3029461577 cites W2056426365 @default.
- W3029461577 cites W2057264876 @default.
- W3029461577 cites W2062452443 @default.
- W3029461577 cites W2064843672 @default.
- W3029461577 cites W2096569657 @default.
- W3029461577 cites W2098499808 @default.
- W3029461577 cites W2099530831 @default.
- W3029461577 cites W2107870851 @default.
- W3029461577 cites W2131325881 @default.
- W3029461577 cites W2144693601 @default.
- W3029461577 cites W2148889365 @default.
- W3029461577 cites W2169125742 @default.
- W3029461577 cites W2235242562 @default.
- W3029461577 cites W2264179442 @default.
- W3029461577 cites W2274552714 @default.
- W3029461577 cites W2312454196 @default.
- W3029461577 cites W2324967283 @default.
- W3029461577 cites W2405999092 @default.
- W3029461577 cites W2407428842 @default.
- W3029461577 cites W2415430012 @default.
- W3029461577 cites W2438868888 @default.
- W3029461577 cites W2729548803 @default.
- W3029461577 cites W2770026599 @default.
- W3029461577 cites W2770894496 @default.
- W3029461577 cites W2781601109 @default.
- W3029461577 cites W2808260248 @default.
- W3029461577 cites W295353521 @default.
- W3029461577 cites W2970203488 @default.
- W3029461577 cites W2996796737 @default.
- W3029461577 cites W3001616644 @default.
- W3029461577 cites W3115184327 @default.
- W3029461577 doi "https://doi.org/10.3389/fgene.2020.00595" @default.
- W3029461577 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7308547" @default.
- W3029461577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32612638" @default.
- W3029461577 hasPublicationYear "2020" @default.
- W3029461577 type Work @default.
- W3029461577 sameAs 3029461577 @default.
- W3029461577 citedByCount "27" @default.
- W3029461577 countsByYear W30294615772020 @default.
- W3029461577 countsByYear W30294615772021 @default.
- W3029461577 countsByYear W30294615772022 @default.
- W3029461577 countsByYear W30294615772023 @default.
- W3029461577 crossrefType "journal-article" @default.
- W3029461577 hasAuthorship W3029461577A5000294110 @default.
- W3029461577 hasAuthorship W3029461577A5015770154 @default.
- W3029461577 hasAuthorship W3029461577A5016052822 @default.
- W3029461577 hasAuthorship W3029461577A5018061261 @default.
- W3029461577 hasAuthorship W3029461577A5022147892 @default.
- W3029461577 hasAuthorship W3029461577A5022439983 @default.
- W3029461577 hasAuthorship W3029461577A5028292731 @default.
- W3029461577 hasAuthorship W3029461577A5029734133 @default.
- W3029461577 hasAuthorship W3029461577A5034424670 @default.