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- W3029479670 abstract "ObjectivesTo clarify the differential diagnostic value for iron deficiency anemia(IDA)and anemia of chronic disease(ACD)with analysis method of multiple parameters.MethodsThe serum concentrations of iron parameters(SI, TIBC, TF, SF and sTfR), inflammatory index(IL-1, IL-6, TNF-β), CRP and hepcidin were detected in patients with IDA and ACD by biochemical method and ELISA respectively.ResultsIn the differential diagnosis of IDA versus ACD, the SF(98.6 versus 6.0, P=0)and sTfR/logSF〔(13.1±4.4) versus (27.6±16.5), P=0.002〕had clinical value for the differential diagnosis.Inflammatory factors level was increased in two groups, only the difference in CRP between IDA and ACD showed a statistical significance.The hepcidin had the clinical value in differential diagnosis for single disease diagnosis of IDA and ACD and for differential diagnosis between IDA and ACD〔(144.6±1.9) versus (86.5±3.1), P<0.05〕. Correlation analysis showed that the sTfR/logSF had a significantly negative correlation with SI(P=0.002), a significantly positive correlation with TIBC and TRF, and no significant correlation with inflammatory factors.The hepcidin had significantly positive correlation with IL-6 and TNF-β, and a significantly negative correlation with SI.The positive correlation was observed between sTfR/logSF and Hepcidin(r=0.376, P=0.005).ConclusionsAnalysis method of multiple parameters could make a differential diagnosis of ACD in the elderly.Key words: Chronic disease; Anemia; Iron-regulatory proteins; Cytokines" @default.
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- W3029479670 date "2017-01-14" @default.
- W3029479670 modified "2023-09-23" @default.
- W3029479670 title "The clinical differential diagnostic value of multiple parameters analysis method for anemia of chronic disease in elderly patients" @default.
- W3029479670 doi "https://doi.org/10.3760/cma.j.issn.0254-9026.2017.01.014" @default.
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