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- W3029481839 abstract "Objective To investigate the metabolic features of hippocampus in suicide-attempted depression by proton resonance spectroscopy(1H-MRS). Methods 1H-MRS was performed on bilateral hippocampi in 24 suicide-attempted depressions and 24 healthy controls. The ratios of N-acetylasparte (NAA)/creatine (Cr),choline(Cho)/Cr and myoinositol (mI)/Cr were calculated, and were used as observation marker reflecting the metabolic level of NAA, Cho and mI. The differences among all maskers in bilateral hippoeampi between the suicide-attempted depression and the control were analyzed. And differences between the left hippocampus and the right among all metabolic markers and lateralization index were used to determine the asymmetry of hippocampus metabolic. Results The ratio of NAA/Cr in the left hippocampus in suicide-attempted was significantly decreased than that in the control ( P 0.05). No correlations among all metabolic markers with the course of disease, number of episodes and HAMD17 scores and drug usage was found in the suicide-attempted depression( P>0.05). Conclusion Metabolite of NAA/Cr in left hippocampus decreased and an asymmetry of bilateral hippocampi can not be seen in the suicide-attempted depression.Key words: Suicide; Depression; Hippocampus ; Magnetic resonance spectroscopy" @default.
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- W3029481839 date "2008-06-20" @default.
- W3029481839 modified "2023-09-23" @default.
- W3029481839 title "A proton magnetic spectroscopy research on hippocampus in suicide-attempted depression" @default.
- W3029481839 doi "https://doi.org/10.3760/cma.j.issn.1005-8559.2008.06.021" @default.
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