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- W3029490716 abstract "ObjectiveTo explore the influence of changes of serum copper and zinc ions on the attack of bipolar disorder.MethodsClinical data of 64 bipolar disorder patients being diagnosed and treated and 30 healthy volunteers in the First Affiliated Hospital of Jinan University from August 2013 to February 2015 were retrospectively analyzed. Among the 94 subjects, 43 were males and 51 were females with an average age of (28±10) years old. The informed consents were obtained from all of the subjects and the local ethical committee approval had been received. According to the mood states, all the subjects were divided into 3 groups: 32 patients in the acute episode of bipolar disorder, 32 patients in the remission episode of bipolar disorder and 30 subjects in the control group. Copper ion, zinc ion and ceruloplasmin were tested by collecting every subject’s venous blood in fasting state in the morning. The comparisons of clinical and experimental data among the 3 groups were conducted using ANOVA analysis, with LSD-t test for pairwise comparison; and comparisons between two sexes were conducted using χ2 test.ResultsThe concentrations of copper ion and ceruloplasmin and copper/zinc ratio of the patients in acute episode of bipolar disorder were significantly lower than those of the control group (LSD-t=–2.32, –0.11, –0.74, P 0.05).ConclusionsThe patients with bipolar disorder can encounter abnormal concentrations of copper and zinc in both acute and remission episodes. The concentration changes of copper and zinc ions may become one of the characteristic performances to monitor trace element for bipolar disorder; however, the changing mechanism remains to be investigated.Key words: Bipolar disorder; Trace element; Copper; Zinc" @default.
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- W3029490716 date "2016-11-30" @default.
- W3029490716 modified "2023-09-25" @default.
- W3029490716 title "Influence of the changes of serum copper and zinc ions on the attack of bipolar disorder" @default.
- W3029490716 doi "https://doi.org/10.3877/cma.j.issn.2095-9605.2016.04.009" @default.
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