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- W3029490925 abstract "Objective To provide reliable support for the application of neoadjuvant therapy for advanced rectal cancer by exploring the impacts of the therapy on apoptosis,proliferation,and invasive ability of the cancer cells.Methods Postoperative paraffin sections from patients receiving neoadjuvant therapy ( study group ) and from those receiving no neoadjuvant therapy ( control group ) were examined.The expression differences of oncobiology-associated markers including carcino-embryonic antigen ( CEA ),proliferating cell nuclear antigen ( PCNA ),and vascular endothelial growth factor receptor2 ( VEGFR2 ) were compared between the two groups.Results The positive rates of CEA,PCNA,and VEGFR2 were significantly lower in the study group than in the control group ( 98.33％ vs.83.33％,X2=9.08,P=0.028 for CEA ; 96.67％vs.83.33％,X2=9.51,P=0.023forPCNA; and81.67％vs.46.67％,X 2=16.32,P=0.001 for VEGFR2 ).Conclusions Neoadjuvant therapy can reduce the invasive ability of rectal cancer cells,which may be beneficial to the prognosis of patients with rectal cancer.Key words: Rectal cancer; Necadjuvant therapy; Biological characteristics" @default.
- W3029490925 created "2020-06-05" @default.
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- W3029490925 date "2011-11-01" @default.
- W3029490925 modified "2023-09-23" @default.
- W3029490925 title "Impact of neoadjuvant therapy on the biological characteristics of rectal cancer cells" @default.
- W3029490925 doi "https://doi.org/10.3760/cma.j.issn.1007-1245.2011.21.001" @default.
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