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- W3029496090 abstract "ObjectiveTo investigate the expressions of proline-rich tyrosine kinase-2 (Pyk2), vascular endotheliar growth factor (VEGF), and N-cadherin in hepatocellular carcinomas and their clinical significances.MethodsThe expressions of Pyk2, VEGF, and N-cadherin proteins were tested with immunohistochemistry in 80 cases of hepatocellular carcinomas and adjacent paracancerous tissues.ResultsThe positive rates of Pyk2, VEGF, and N-cadherin in hepatocellular carcinomas were significantly higher than adjacent paracancerous tissues (71.3% vs 12.0%; 63.8% vs 8.0%; 57.5% vs 10.0%, P<0.05). The differences in the expressions of Pyk2, VEGF, and N-cadherin in hepatocellular carcinoma of pathological grading, tumor differentiation, vascular invasion and clinical tumor node metastasis (TNM) stage were significant (P<0.05). Significantly positive correlation was found between Pyk2 and VEGF or N-cadherin with Spearman correlation analysis (all P<0.05). There was positive correlation between N-cadherin and VEGF (P<0.05).ConclusionsThe abnormal expressions of Pyk2, VEGF, and N-cadherin genes may promote tumor angiogenesis and progression of hepatocellular carcinoma. Pyk2 may provide an important reference for prognostic evaluation of hepatocellular carcinoma.Key words: Protein-tyrosine kinases/ME; Vascular endothelial growth factors/ME; Cadherins/ME; Carcinoma, hepatocellular/ME/PA" @default.
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- W3029496090 date "2016-11-20" @default.
- W3029496090 modified "2023-09-26" @default.
- W3029496090 title "Expressions and significances of Pyk2, VEGF and N-cadherin in hepatocellular carcinoma" @default.
- W3029496090 doi "https://doi.org/10.3760/cma.j.issn.1008-1372.2016.11.017" @default.
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