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- W3029506121 abstract "ObjectiveTo investigate the expression of microRNA (miRNA) -3620 in the plasma of patients with anti-tuberculosis drug-induced hepatotoxicity (ATDH).MethodsA total of 35 patients with ATDH and 35 non-ATDH paired individuals were included in this study. Plasma miRNA-3620 levels were detected using real-time Polymerase chain reaction. Comparison between two groups was done with t test. Receiver operation characteristic (ROC) curve analysis was performed to determine the diagnostic value of miRNA-3620 in ATDH.ResultsThe relative expression of plasma miRNA-3620 of patients with ATDH and non-ATDH were 1.65±1.43 and 0.71±0.45, respectively, with significantly statistical difference (t=3.703, P<0.01). The cut off value of miRNA-3620 expression was 1.15 and the area under ROC curve were 0.71(95% CI: 0.43—1.45). Based on this cutoff value, the sensitivity and specificity of miRNA-3620 in diagnosing ATDH were 60.0% and 82.9%, respectively; the positive predictive value was 77.8% and the negative predictive value was 67.4%. Twenty-one ATDH cases and 29 non-ATDH cases was correctly diagnosed, with the accuracy of 71.4%.ConclusionThe expression of miRNA-3620 in plasma is significantly increased in ATDH patients.Key words: miRNA-3620; Anti-tuberculosis drug-induced hepatotoxicity; Tuberculosis, pulmonary" @default.
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- W3029506121 date "2017-03-15" @default.
- W3029506121 modified "2023-10-08" @default.
- W3029506121 title "Expression of microRNA-3620 in blood plasma and its clinical significance in patients with anti-tuberculosis drug-induced hepatotoxicity" @default.
- W3029506121 doi "https://doi.org/10.3760/cma.j.issn.1000-6680.2017.03.008" @default.
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