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• W3029510246 abstract "ObjectiveTo study the effects of pyruvate-containing hydroxyethyl starch (HES 130/0.4) on renal blood flow and kidney function in rats subjected with 50% total body surface area Ⅲ degree burns.MethodsOne hundred and eighty SD rats, of which 160 rats were subjected to a 50% total body surface area burn, were divided into five groups: burns without fluid resuscitation(n=20), shame control group(n=40), burns with pyruvate-containing hydroxyethyl starch group (n=40), burns with acetate-containing hydroxyethyl starch group (n=40), and burns with normal saline-containing hydroxyethyl starch group (n=40), the front two groups were no resuscition, otherwise fluid infusion was taken via the jugular vein catheter to the after groups, using a trace infusion pump controlled theinfusion speed. The total amount of fluids infused was 0.75 ml/kg × 1% total body surface area (1/2 colloidal rehydration formula) of various hydroxyethyl starch and the equal volume of acetated Ringer′s solution with the colloid to crystalloid ratio of 1∶1 within 12 h post-resuscittion burns. Burn in 4 h with acetated Ringer′s solution, then in after 8 h with different colloid. Each group was further divided into four subgroups: 4 h, 8 h, 12 h, and 24 h after scald (n=10). Laser doppler blood flow meter determination of renal blood flow, automatic biochemical analyzer of creatinine and urea nitrogen content in the blood plasma were measured. SPSS 17.0 statistical software package be used to analyze the data, with two comparison using single factor analysis of variance between groups.ResultsAt 4 h and 8 h after burns, the renal blood flow level in burns without fluid resuscitation (32.10±6.40, 11.80±5.43) BPU of rats were lower than those in shame control group (146.50±23.73, 144.80±24.27) BUP, the difference was statistically significant (P<0.05); At 4 h, 8 h, 12 h and 24 h after burns, the renal blood flow of burns with pyruvate-containing hydroxyethyl starch group, burns with acetate-containing hydroxyethyl starch group, and burns with normal saline-containing hydroxyethyl starch group were(46.40±8.14, 104.80±22.75, 89.40±12.07, 77.10±10.78), (45.50±8.21, 77.20±13.19, 70.60±10.55, 56.90±8.49), (45.30±8.76, 58.10±11.32, 51.70±9.65, 40.20±8.25)BPU, which were all significantly lower than those in shame control group(146.50±23.73, 144.80±24.27, 147.60±26.55, 143.20±23.94)BPU, the difference was statistically significant (P<0.05); At 8 h, 12 h and 24 h after burns, the renal blood flow of burns with pyruvate-containing hydroxyethyl starch group was higher than burns with acetate-containing hydroxyethyl starch group and burns with normal saline-containing hydroxyethyl starch group, and burns with acetate-containing hydroxyethyl starch group was higher than burns with normal saline-containing hydroxyethyl starch group, the difference was statistically significant(P<0.05). At 24 h after burns, the Cr level of burns with pyruvate-containing hydroxyethyl starch group was(66.70±6.67)μmol/L, which was significantly lower than burns with acetate-containing hydroxyethyl starch group(80.20±9.97)μmol/L and normal saline-containing hydroxyethyl starch group (91.30±9.50) μmol/L(P<0.05), the difference was statistically significant(P<0.05); and BUN of pyruvate-containing hydroxyethyl starch group was (29.00±2.48) mmol/L, which was also significantly lower than, the difference was statistically significant(P<0.05).ConclusionsThe carrier of HES 130/0.4 played a critical role in renal blood flow and kidney function in resuscitation of rats subjected with 50% total body surface area Ⅲ burns. The sodium pyruvate-containing hydroxyethyl starch might be superior to sodium acetate and normal saline-containing hydroxyethyl starch in preservation of kidney functionduring fluid resuscitation in rats with severe burn injury.Key words: Hetastarch; Burns; Ischemia; Renal blood flow, effective; Kidney function; Pyruvate" @default.
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• W3029510246 date "2015-10-01" @default.
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• W3029510246 title "Effects of sodium pyruvate-hydroxyethyl starch on renal blood flow and kidney function in rats with 50% total body surface area full thickness scald injury" @default.
• W3029510246 doi "https://doi.org/10.3877/cma.j.issn.1673-9450.2015.05.004" @default.
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