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- W3029510904 abstract "ObjectiveTo investigate the influence of neoadjuvant chemotherapy on the occurrence of postoperative nausea and vomiting (PONV) after radical mastectomy.MethodsA total of 286 breast cancer patients, aged 18-60 yr, of American Society of Anesthesiologists physical status Ⅰ or Ⅱ, scheduled for elective modified radical mastectomy under general anesthesia in our hospital, were divided into either non-chemotherapy group (n=106) or neoadjuvent chemotherapy group (n=180). General anesthesia was induced with iv propofol 2 mg/kg, rocuronium 0.6 mg/kg and sufentanil 0.2 μg/kg.The patients were endotracheally intubated.The concentration of sevoflurane inhaled was adjusted according to the value of bispectral index, and bispectral index value was maintain at 40-50.Ondansetron 8 mg and flurbiprofen axetil 100 mg were injected intravenously at 30 min before the end of surgery.If vomiting occurred for 2 consecutive times, and continuous nausea and vomiting appeared from the time point after extubation to 24 h after surgery, and the patients required treatment, rescue medication was used.The occurrence and severity of PONVwithin 24 h after surgery and requirement for rescue medication were recorded.ResultsCompared with non-chemotherapy group, the incidence of PONV within 24 h after surgery and requirement for rescue medication were significantly increased, and the severity of PONV was aggravated in neoadjuvent chemotherapy group (P<0.05).ConclusionNeoadjuvant chemotherapy before surgery can increase the risk and severity of PONV after modified radical mastectomy.Key words: Antineoplastic combined chemotherapy protocols; Postoperative complications; Breast neoplasms" @default.
- W3029510904 created "2020-06-05" @default.
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- W3029510904 date "2015-12-20" @default.
- W3029510904 modified "2023-09-27" @default.
- W3029510904 title "Influence of neoadjuvant chemotherapy on occurrence of postoperative nausea and vomiting after radical mastectomy" @default.
- W3029510904 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2015.12.002" @default.
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