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- W3029523680 abstract "ObjectiveTo study the expression and clinical importance of non-receptor protein tyrosine phosphatases (PTPN) in patients with rheumatoid arthritis (RA).MethodsThirty-two RA patients enrolled in our hospital from February 2015 to October 2015 and 29 healthy controls were recruited. Peripheral blood was obtained and mononuclear cells were prepared using Ficoll density gradient centrifugation. The expression of protein tyrosine phosphatases (PTPs) mRNA and protein was detected by real-time quantitative reverse transcriptase-polymerase chain reaction (RT-qPCR) and immunoblot respectively. Meanwhile, the levels of inflammatory factors like interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α and biochemical indexes like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were evaluated, with the calculation of DAS28, a measure of disease activity in RA. The correlation between PTPs and inflammatory factors, or biochemical indexes, or DAS28 was analyzed.ResultsIn comparison with the controls, the expression of PTPN1, PTPN2, PTPN3, PTPN4, PTPN7, PTPN9, PTPN13 was reduced, while that of PTPN11 (2.530±0.743 vs. 1.000±0.034) and PTPN14 (2.269±0.548 vs. 1.000±0.057) was augmented in RA patients. The expression of PTPN11 was positively correlated with TNF-α levels [(5.95±1.57) ng/ml, r=0.669, P=0.000], CRP levels [(28.58±6.72) mg/L, r=0.795, P=0.000] and DAS28 score [(4.20±0.73) points, r=0.703, P=0.000]. PTPN14 was positively correlated with TNF-α (r=0.633, P=0.000) and CRP level (r=0.435, P=0.013), but not with DAS28 score (r=0.033, P=0.856).ConclusionPTPs were expressed differently in peripheral mononuclear cells of RA patients. Among them, PTPN11 expression was correlated with inflammatory factors, CRP level and DAS28, which may serve as novel markers in RA diagnosis.Key words: Non-receptor protein tyrosine phosphatases; Rheumatoid arthritis; Mononuclear cells; Inflammatory factor; DAS28" @default.
- W3029523680 created "2020-06-05" @default.
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- W3029523680 date "2017-05-08" @default.
- W3029523680 modified "2023-09-25" @default.
- W3029523680 title "Expression of non-receptor protein tyrosine phosphatases in peripheral blood mononuclear cells of patient with rheumatoid arthritis" @default.
- W3029523680 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2017.05.052" @default.
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