FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029546670> ?p ?o ?g. }

• W3029546670 endingPage "853" @default.
• W3029546670 startingPage "840" @default.
• W3029546670 abstract "Summary Cryptococcal meningitis remains one of the leading causes of death among HIV‐infected adults in the fourth decade of HIV era in sub‐Saharan Africa, contributing to 10%–20% of global HIV‐related deaths. Despite widespread use and early induction of ART among HIV‐infected adults, incidence of cryptococcosis remains significant in those with advanced HIV disease. Cryptococcus species that causes fatal infection follows systemic spread from initial environmental acquired infection in lungs to antigenaemia and fungaemia in circulation prior to establishment of often fatal disease, cryptococcal meningitis in the CNS. Cryptococcus person‐to‐person transmission is uncommon, and deaths related to blood infection without CNS involvement are rare. Keen to the persistent high mortality associated with HIV‐cryptococcal meningitis, seizures are common among a third of the patients, altered mental status is frequent, anaemia is prevalent with ensuing brain hypoxia and at autopsy, brain fibrosis and infarction are evident. In addition, fungal burden is 3‐to‐4‐fold higher in those with seizures. And high immune activation together with exacerbated inflammation and elevated PD‐1/PD‐L immune checkpoint expression is immunomodulated phenotypes elevated in CSF relative to blood. Lastly, though multiple Cryptococcus species cause disease in this setting, observations are mostly generalised to cryptococcal infection/meningitis or regional dominant species ( C neoformans or gattii complex ) that may limit our understanding of interspecies differences in infection, progression, treatment or recovery outcome. Together, these factors and underlying mechanisms are hypotheses generating for research to find targets to prevent infection or adequate therapy to prevent persistent high mortality with current optimal therapy." @default.
• W3029546670 created "2020-06-05" @default.
• W3029546670 creator A5000504924 @default.
• W3029546670 creator A5027410574 @default.
• W3029546670 creator A5064975634 @default.
• W3029546670 creator A5072064998 @default.
• W3029546670 date "2020-06-19" @default.
• W3029546670 modified "2023-10-14" @default.
• W3029546670 title "Landmark clinical observations and immunopathogenesis pathways linked to HIV and <i>Cryptococcus</i> fatal central nervous system co‐infection" @default.
• W3029546670 cites W1039201796 @default.
• W3029546670 cites W1508350471 @default.
• W3029546670 cites W1517668104 @default.
• W3029546670 cites W1617971067 @default.
• W3029546670 cites W1802265303 @default.
• W3029546670 cites W1816895742 @default.
• W3029546670 cites W1969451874 @default.
• W3029546670 cites W1972160809 @default.
• W3029546670 cites W1973682314 @default.
• W3029546670 cites W1974039861 @default.
• W3029546670 cites W1975913203 @default.
• W3029546670 cites W1980954479 @default.
• W3029546670 cites W1982595765 @default.
• W3029546670 cites W1983973479 @default.
• W3029546670 cites W1992943210 @default.
• W3029546670 cites W2001701680 @default.
• W3029546670 cites W2003105635 @default.
• W3029546670 cites W2007157312 @default.
• W3029546670 cites W2011253674 @default.
• W3029546670 cites W2014357222 @default.
• W3029546670 cites W2026004843 @default.
• W3029546670 cites W2029613048 @default.
• W3029546670 cites W2036015748 @default.
• W3029546670 cites W2036182825 @default.
• W3029546670 cites W2042384977 @default.
• W3029546670 cites W2042851093 @default.
• W3029546670 cites W2044253229 @default.
• W3029546670 cites W2046696762 @default.
• W3029546670 cites W2049532563 @default.
• W3029546670 cites W2058798829 @default.
• W3029546670 cites W2066572646 @default.
• W3029546670 cites W2067090650 @default.
• W3029546670 cites W2068243193 @default.
• W3029546670 cites W2068790641 @default.
• W3029546670 cites W2072043666 @default.
• W3029546670 cites W2079513681 @default.
• W3029546670 cites W2080471324 @default.
• W3029546670 cites W2087450881 @default.
• W3029546670 cites W2094073820 @default.
• W3029546670 cites W2095601290 @default.
• W3029546670 cites W2099443640 @default.
• W3029546670 cites W2101195119 @default.
• W3029546670 cites W2104724785 @default.
• W3029546670 cites W2105512727 @default.
• W3029546670 cites W2107455390 @default.
• W3029546670 cites W2107809091 @default.
• W3029546670 cites W2111962782 @default.
• W3029546670 cites W2113417401 @default.
• W3029546670 cites W2114424988 @default.
• W3029546670 cites W2114512094 @default.
• W3029546670 cites W2114888966 @default.
• W3029546670 cites W2116173177 @default.
• W3029546670 cites W2117826414 @default.
• W3029546670 cites W2118425309 @default.
• W3029546670 cites W2120465011 @default.
• W3029546670 cites W2127008679 @default.
• W3029546670 cites W2131056555 @default.
• W3029546670 cites W2131640081 @default.
• W3029546670 cites W2135735498 @default.
• W3029546670 cites W2141665312 @default.
• W3029546670 cites W2141967665 @default.
• W3029546670 cites W2143580680 @default.
• W3029546670 cites W2145703939 @default.
• W3029546670 cites W2154447377 @default.
• W3029546670 cites W2155330030 @default.
• W3029546670 cites W2156120863 @default.
• W3029546670 cites W2158915748 @default.
• W3029546670 cites W2159361186 @default.
• W3029546670 cites W2161558877 @default.
• W3029546670 cites W2170501001 @default.
• W3029546670 cites W2171241954 @default.
• W3029546670 cites W2219027175 @default.
• W3029546670 cites W2287256905 @default.
• W3029546670 cites W2301515547 @default.
• W3029546670 cites W2318982047 @default.
• W3029546670 cites W2336477803 @default.
• W3029546670 cites W2339101724 @default.
• W3029546670 cites W2343954492 @default.
• W3029546670 cites W2344621181 @default.
• W3029546670 cites W2344848358 @default.
• W3029546670 cites W2414962288 @default.
• W3029546670 cites W2477420425 @default.
• W3029546670 cites W2516869096 @default.
• W3029546670 cites W2520487218 @default.
• W3029546670 cites W2550637220 @default.
• W3029546670 cites W2551198340 @default.
• W3029546670 cites W2561617333 @default.
• W3029546670 cites W2572976193 @default.
• W3029546670 cites W2575099950 @default.

• next