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- W3029557659 abstract "目的 探讨奥氮平合并舒必利治疗难治性精神分裂症的疗效及不良作用.方法对97例难治性精神分裂症患者按CCMD-Ⅲ标准及难治性标准确诊后,随机分成三组,分别用舒必利、奥氮平、舒必利合并奥氮平治疗6个月,在治疗前及治疗后2,4,6个月用BPRS、SANS、SDSS、CGI量表评定疗效.结果研究结果显示三种方法治疗难治性精神分裂症6个月后均有效,舒必利、奥氮平、舒必利合并奥氮平三组有效率分别为59.4%、30.0%、37.9%.三组在治疗后2,4,6个月BPRS、SANS评分与治疗前相比较均有显著下降,差异有非常显著性(P <0.01),舒必利合并奥氮平治疗有效率与另两组比较差异有非常显著性(P <0.01),治疗后2,4,6个月BPRS、SANS减分率与另两组比较差异具有显著性(P <0.05).舒必利合并奥氮平的不良反应明显减少,主要为窦性心动过速、EPS、便秘、体重增加.结论三种方法治疗难治性精神分裂症6个月均有效,舒必利合并奥氮平较单一用药更有效,不良反应少。" @default.
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- W3029557659 date "2005-07-20" @default.
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- W3029557659 title "Clinical controlled studies of olanzapine combined with sulpiride therapy in refractory schizophrenia" @default.
- W3029557659 doi "https://doi.org/10.3760/cma.j.issn.1005-8559.2005.07.027" @default.
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