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- W3029558765 abstract "Abstract Comprehensive functional analyses of E ‐isoprenyl diphosphate synthases ( E ‐IDSs) from nonpathogenic Mycobacterium vanbaalenii have been performed. Mv0992 and Mv1577 represent a nonaprenyl diphosphate ( E ‐C 45 ) synthase and a geranylgeranyl diphosphate ( E ‐C 20 ) synthase, respectively. Although Mv3536 was identified as an E ‐C 20 synthase using a single enzyme, co‐incubation of Mv3536 and Z ‐IDSs (Mv4662 and Mv3822) strongly suggested it releases an intermediate geranyl diphosphate ( E ‐C 10 ) during a continuous condensation reaction. Mv0992 and Mv3536 functions differed from those of the previously reported pathogenic Mycobacterium tuberculosis homologues Rv0562 and Rv2173, respectively. Re‐analysis of Rv0562 and Rv2173 demonstrated that their functions were similar to those of Mv0992 and Mv3536 (Rv0562: E ‐C 45 synthase; Rv2173: E ‐C 10–15 synthase). The newly proposed functions of Rv0562 and Rv2173 would be in the biosynthesis of menaquinone and glycosyl carrier lipids essential for growth. Furthermore, a reduced allylic diphosphate could be used as the Z ‐IDS of the Mv3822 substrate, thereby introducing a potentially novel pathway of cyclic sesquarterpene biosynthesis." @default.
- W3029558765 created "2020-06-05" @default.
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- W3029558765 date "2020-07-14" @default.
- W3029558765 modified "2023-10-13" @default.
- W3029558765 title "Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from <i>Mycobacterium vanbaalenii</i> and <i>Mycobacterium tuberculosis</i>" @default.
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- W3029558765 doi "https://doi.org/10.1002/cbic.202000235" @default.
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