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- W3029565735 abstract "Objective To explore the role of Annexin Ⅱ and urokinase-type plasminogen activator(uPA) proteins in the development and lymph node metastasis of thyroid cancer.Methods Immunohistochemistry was used to detect the expression of Annexin Ⅱ and uPA proteins in 35 cases of papillary thyroid cancer tissues,10 cases of thyroid adenoma tissues,16 cases of nodular goiter tissues and 7 cases of normal thyroid tissues.Results The positive expression rate of Annexin Ⅱ and uPA protein was significantly higher in papillary thyroid cancer than in normal thyroid tissues,nodular goiter tissues and thyroid adenoma tissues( P ＜0.05 ).The expression of Annexin Ⅱ and uPA protein was positively correlated in papillary thyroid cancer tissues(P ＜0.05).The expression of Annexin Ⅱ protein in thyroid cancer tissues was associated with tumor size and lymph node metastasis while the expression of uPA protein was only related to lymph node metastasis.Conclusions Annexin Ⅱ and uPA proteins are involved in the occurrence and development of papillary thyroid cancer.They also play a facilitating role in lymph node metastasis of papillary thyroid cancer.Key words: Papillary thyroid cancer; Annexin Ⅱ; uPA; Immunohistochemistry; Metastasis" @default.
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- W3029565735 date "2012-08-25" @default.
- W3029565735 modified "2023-09-24" @default.
- W3029565735 title "Expression of Annexin II and uPA in thyroid cancer and their clinical significances" @default.
- W3029565735 doi "https://doi.org/10.3760/cma.j.issn.1674-6090.2012.04.001" @default.
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