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- W3029592412 abstract "CXCL12-induced signalling pathway plays an important role in regulating the activation and recruitment of immunocytes,mobilization and homing of hematopoietic stem cells,neo-angiogenesis,embryogenesis,invasion and metastasis of tumor cells.Rencently,the regulation of CXCL12/CXCR4/CXCR7 axis in placental implantation and development has aroused considerable attention.Related studies suggest that CXCL12-induced signalling can not only regulate differentiation,proliferation and invasion of placental trophoblast cells,but also induce trophoblast directed migration into decidual stromal tissues and blood vessels,promote placental implantation,uteroplacental vascular remodeling,materno-fetal immune tolerance,which further maintains the progression of pregnancy.A better understanding of the mechanism of CXCL12/CXCR4/CXCR7 axis in the maintenance of trophoblast functions may give insight into the process of placental implantation,hope fully offering a novel treatment strategy for trophoblast cells dysfunction-related diseases.Key words: Chemokine; Chemokine receptor; Trophoblast; Signal transduction" @default.
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- W3029592412 date "2014-09-05" @default.
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- W3029592412 title "Roles of CXCL12/CXCR4/CXCR7 axis in placental trophoblasts and related mechanisms" @default.
- W3029592412 doi "https://doi.org/10.3760/cma.j.issn.1673-4394.2014.05.004" @default.
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