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- W3029593899 abstract "Dendritic cells (DCs) can capture HIV from the mucosal site and carry it to the draining lymph nodes to promote CD4+ T cell infection. DC-SIGN(CD209) plays a vital role during this process. Heroin, methamphetamine and cocaine are the most abused drugs used by drug abusers, which can increase the opportunities of HIV infection. Drugs acting on the corresponding receptors activate the downstream signaling pathway and regulate the expression of DC-SIGN on the surface of DCs, weakening the inhibited effects of immune cells on HIV and promoting HIV infection in many aspects. Given the multiplex effects of drugs on immune function, this article reviews the relationship between abused drugs, DCs and HIV infection, particularly in the signal pathway on immune modulation.Key words: HIV; Dendritic cells; Heroin; Cocaine; Methamphetamine" @default.
- W3029593899 created "2020-06-05" @default.
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- W3029593899 date "2017-02-28" @default.
- W3029593899 modified "2023-09-27" @default.
- W3029593899 title "Research advances of the effect of commonly used drugs on dendritic cell function and HIV infection" @default.
- W3029593899 doi "https://doi.org/10.3760/cma.j.issn.1674-2397.2017.01.014" @default.
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