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- W3029615280 abstract "Circular RNA is a kind of single-stranded RNA ring without 5′capping and 3′polyadenylation. As a new member of non-coding RNA, circular RNA is evolutionally conserved, relatively stable, highly specific and enormously abundant. Instead of liner RNA, circular RNA became the research hotspot. So far, cerebellar degeneration-related protein 1 antisense (CDR1as) is a molecule that has garnered intense research. CDR1as harbors 74 conventional miRNA-7 binding sites. Expression of CDR1as efficiently tethers micro RNA-7, resulting in reduced micro RNA-7 activity and increased levels of micro RNA-7 targeted transcripts consistent with the micro RNA sponge and competing endogenous RNA (ceRNA) hypothesis. Moreover, CDR1as can restore micro RNA-7 and release it at right time. CDR1as can be stabilized in the exosomes. And its level has correlation with many clinical characteristics.Key words: Tumor markers, biological; Review; Cerebellar degeneration-related protein 1 antisense" @default.
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- W3029615280 date "2018-01-05" @default.
- W3029615280 modified "2023-09-26" @default.
- W3029615280 title "The regulatory role of cerebellar degeneration-related protein 1 antisense" @default.
- W3029615280 doi "https://doi.org/10.3760/cma.j.issn.1673-4904.2018.01.023" @default.
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