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- W3029631330 abstract "Objective To explore the effect of trifluoperazine (TFP) on platelet-derived growth factor (PDGF)-induced cultured human mesangial cell (HMC) apoptosis.Methods The HMCs of logarithmic phase were stimulated with PDGF for 24 h and cultured with 0,10,20 or 30 μmol/L TFP for 48 h.20 μmol/L TFP was used for 0,24,48 or 72 h before flow cytometry was performed to detect the apoptosis of the mesangial cells.The expression of Caspase-3,Bax and Bcl-2 was analyzed after incubated with 20μmol/L of TFP for 48 h by Western blot.Results (1) Compared with the control group,the apoptosis of the PDGF group was significantly decreased (P ＜ 0.05).While compared with the PDGF group,10,20 and 30 μmol/L TFP group's figure was significantly increased (P ＜ 0.05),of which 20 μmol/L TFP group was increased more obviously (P ＜ 0.01).(2)The apoptosis of HMCs was significantly increased in a time-dependent manner after incubated with TFP for 72 h.(3) Compared with the control group,the expression of Caspase 3 and Bax was significantly decreased in the PDGF group,while the expression of Bcl-2 was significantly increased.Conclusions TFP could induce apoptosis in a concentrationand time-dependent manner.The mechanism may be related to the change of Bcl-2/Bax and the activation of Caspase-3.Key words: Trifluoperazine; Human mesangial cells; Platelet-derived growth factor; Apoptosis" @default.
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- W3029631330 date "2014-07-20" @default.
- W3029631330 modified "2023-09-24" @default.
- W3029631330 title "Effect of trifluoperazine on apoptosis of cultured human mesangial cells in vitro" @default.
- W3029631330 doi "https://doi.org/10.3760/cma.j.issn.1673-4238.2014.04.009" @default.
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