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- W3029656002 abstract "Background Recent studies demonstrate that iron accumulation in cells can produce toxicity and impair the function of cells.Divalent metal transporter-1 (DMT1),a membrane protein transporting metal ions,plays a pivotal role in intestinal nonheme-iron absorption and iron acquisition by cells.Recent data shows that when cerebral artery infarction occurs,thc iron accumulates in neurons,whereas inhibition of DMT1 by some effective approaches decreases the iron accumulation in neurons and improves mammal's cognitive state.Objective To assess the mechanisms of cognitive dysfunction induced by DMT1-mediated iron accumulation after cerebral ischemia.Content This review presents the mechanisms of iron absorption and releasing for neurons,molecular structures and physiological functions of DMT1,effects of DMT1 on iron accumulation after cerebral ischemia,effects and mechanisms of iron accumulation on cognition after cerebral ischemia.Trend By assessing the role of pathophysiological mechanisms of DMT1 after cerebral ischemia,it is possible to provide novel approach relieving cognitive dysfunction after cerebral artery infarction.Key words: Divalent metal transporter-1 ; Cerebral ischemia; Iron accumulation; Cognitive dysfunction" @default.
- W3029656002 created "2020-06-05" @default.
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- W3029656002 date "2014-11-15" @default.
- W3029656002 modified "2023-09-23" @default.
- W3029656002 title "The research for mechanisms of cognitive dysfunction induced by divalent metal transporter-1-mediated neurons iron accumulation after cerebral ischemia" @default.
- W3029656002 doi "https://doi.org/10.3760/cma.j.issn.1673-4378.2014.11.017" @default.
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