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- W3029658442 abstract "ObjectiveTo investigate the correlation between recurrence of the primary hepatocellular carcinoma (HCC) after liver transplantation and the expression of CK19 and GPC3.MethodThe clinical and pathological data of 130 cases of liver transplant patients in You An Hospital, Capital Medical University due to HCC from May 20, 2005 to September 15, 2014 were retrospectively analyzed. The mean follow-up time was 28 months (range, 1 to 90 months) after liver transplantation. During liver transplantation, the liver tissues of all the recipients were obtained for HE staining and immunohistochemical staining for CK19 and GPC3. The pathological changes and expression of CK19 and GPC3 were observed under the light microscopy. All cases were followed up. Kaplan-Meier and Cox method was used to analyze the relapse of patients.ResultIn 130 cases of liver transplant patients collected, 64 cases of recurrence occurred. Based on the expression of GPC3 and CK19 staining, the recurrent cases were divided into three groups: CK19+ GPC3+ phenotype (23 cases, 17.7%), CK19-GPC3+ phenotype (65 cases, 50%), and CK19-GPC3- phenotype (42 cases, 32.3%). There were 14 cases of recurrence in CK19+ GPC3+ (60.9%, recurrence time of 1 to 76 months after operation), 37 in CK19-GPC3+ (56.9%, recurrence time of 1 to 77 months after operation), and 13 in CK19-GPC3- (31.0%, recurrence time of 4 to 90 months after operation). There was significant difference among the 3 groups (P<0.05). The recurrence time after operation in CK19+ GPC3+ group and CK19-GPC3+ group was earlier than in CK19-GPC3- group (P<0.017), and there was no significant difference between CK19+ GPC3+ group and CK19-GPC3+ group. CK19/GPC3 grouping was an independent risk prognostic factor.ConclusionThe recurrence of HCC patients after liver transplantation was closely correlated with the expression of CK19 and GPC3 in tumor cells.Key words: Hepatocellular Carcinoma; Liver Transplantation; CK19; GPC3; Recurrence" @default.
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- W3029658442 date "2015-08-20" @default.
- W3029658442 modified "2023-10-07" @default.
- W3029658442 title "Correlation between recurrence of primary hepatocellular carcinoma after liver transplantation and expression of CK19 and GPC3" @default.
- W3029658442 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2015.08.008" @default.
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