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- W3029683786 abstract "目的 探讨外源性一氧化氮(NO)吸入对于新生猪窒息后心肌损害的保护作用.方法将29只新生猪随机分成假手术组(n=8)、窒息对照组(n=11)和窒息NO组(n=10).窒息对照组与窒息NO组中,通过夹闭气管导管10 min建成新生猪窒息模型.心肺复苏后,窒息对照组予以35%氧(O2)吸入,窒息NO组予以NO 10×10-6+35%O2吸入.连续监测肺动脉平均压(mPAP).复苏后6 h测定血清中肌酸激酶心肌同工酶(CK-MB)和心肌钙蛋白T(cTnT)含量;运用超声心动图检测各项心功能指标,包括左室射血分数(LVEF)、右室射血分数(RVEF)、二尖瓣口舒张期血流E/A比值(ME/A)、三尖瓣口舒张期血流E/A比值(TE/A)、二尖瓣环运动速度e/a比值(Me/a)、三尖瓣环运动速度e/a比值(Te/a);假手术组在相应时间点作了测定.实验结束后进行心肌损伤病理组织学评分. 结果复苏后1～6 h,窒息NO组mPAP维持在较低的水平[(14±6)～(12±4)mm Hg],显著低于窒息对照组[(23±5)～(19±3)mm Hg,P＜0.01];复苏后6 h,窒息NO组CK-MB和cTnT含量分别为(275±85)IU/L和(0.38±0.28)μg/L,明显低于窒息对照组[(423±1 56)IU/L和(0.85±0.64)μg/L,P＜0.05];窒息NO组RVEF、TE/A、Me/a和Te/a分别为(67.1±7.1)%、1.04±0.15、1.00±0.23和0.98±0.19,均高于窒息对照组[(60.2土7.1)%、0.79±0.21、0.77±0.12和0.78±0.19,P＜0.05];窒息NO组心肌损伤病理学评分为(1.30±0.95)分,低于窒息对照组[(2.82±0.98)分,P＜0.01].结论新生猪窒息后NO 10×10-6持续吸入6 h,不仅能缓解窒息所致的肺动脉高压,并可减轻急性低氧性心肌损害。" @default.
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- W3029683786 date "2004-05-16" @default.
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- W3029683786 title "Inhaled nitric oxide alleviates asphyxia-induced myocardial impairment" @default.
- W3029683786 doi "https://doi.org/10.3760/cma.j.issn.1007-9408.2004.03.006" @default.
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