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- W3029690125 abstract "Objective To study biomarkers by use of surface-enhanced laser desorption ionization time-of-flight mass spectrometry (SELDI-TOF-MS) in the serum from prostate cancer and benign prostatic hyperplasia,and then to explore the relationship between expression of biomarkers and grade of pathology,clinical stage.The mechanic of hormone-refractory prostate cancer (HRPC) was explored.Methods The serums from forty five prostate cancer and forty five benign prostatic hyperplasia(BPH)patients were detected by Immobilized Metal Affinity Capture(IMAC-CU).Samples of 21 androgen-dependent prostate cancer (ADPC) and 21 HRPC were also detected.The data of spectra were analyzed by bioinformatics tools Biomarker Wizard.Results Compared with the spectra of BPH patients,there were 9 potential markers detected in untreated prostate cancer patients,the protein expression levels were high in 7 of which and low in 2 of which.Combined two biomarker(m/z 3771 and m/z 4481) test achieved 86.49% sensitivity an 89.19% specificity in diagnose of prostate cancer.There was statistical difference of expression of different serum biomarkers among different grades of pathology.Compared with the spectra of ADPC,there were 6 potential markers detected in HRPC(P＜0.05). In HRPC two masses were up-regulated and four masses were down regulated.When protein 5185 or 4205 was applied to diagnose HRPC,the sensitivity was 86.7%,80.0% respectively,the specificity was 76.9%,88.5% respectively.Conclusion SELDI-TOF-MS shows great potentiality for prostate cancer in early diagnosis and screening of tumor biomarkers. Combining several biomarkers to detect prostate cancer can improve sensitivity and specificity.There is statistical difference of expression of different Serum biomarkers among different grades of pathology,which have a close relationship with differentiation of tumor.The differential proteins may play important roles in the course of ADPC transferring to HRPC.Detecting differential proteins help to diagnose HRPC,judge prognosis,guide treatment.Key words: Prostatic neoplasms; Protein array analysis; Mass spectrometry" @default.
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- W3029690125 date "2009-09-28" @default.
- W3029690125 modified "2023-09-25" @default.
- W3029690125 title "Study on proteomics of prostate cancer by surface-enhanced laser desorption ionization time-of-flight mass spectrometry" @default.
- W3029690125 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2009.09.014" @default.
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