Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029690841> ?p ?o ?g. }
- W3029690841 abstract "Abstract The sympathetic nervous system (SNS) contributes to immune balance by promoting anti-inflammatory B cells. However, whether B cells possess a self-regulating mechanism by which they modulate regulatory B cell (Breg) function is not well understood. In this study, we investigated the ability of B cells to synthesize catecholamines upon stimulation with different B cell activators. We found, that expression of the enzymes required to generate catecholamines, is upregulated by TLR9. TLR-9-specific expression of tyrosine hydroxylase (TH) correlated with upregulation of adrenergic receptors, enhanced IL-10 production, and with an overexpression of the co-inhibitory ligands PD-L1 and FasL. Moreover, concomitant stimulation of ß1-3-adrenergic receptors together with a BCR/TLR9 stimulus enhances the anti-inflammatory potential of Bregs to suppress CD4 T cells, a crucial population in the pathogenesis of autoimmune diseases, like rheumatoid arthritis. In conclusion, our data show that B cells possess autonomous mechanisms to modulate their regulatory function. These findings help to better understand the function of Bregs in autoimmune diseases and the interplay of sympathetic nervous system and B cell function." @default.
- W3029690841 created "2020-06-05" @default.
- W3029690841 creator A5029194658 @default.
- W3029690841 creator A5034964027 @default.
- W3029690841 creator A5037887802 @default.
- W3029690841 creator A5041667097 @default.
- W3029690841 creator A5043083018 @default.
- W3029690841 creator A5043409022 @default.
- W3029690841 creator A5059827989 @default.
- W3029690841 creator A5089241426 @default.
- W3029690841 date "2020-05-27" @default.
- W3029690841 modified "2023-09-26" @default.
- W3029690841 title "TLR9-activated B cells improve their regulatory function by endogenously produced catecholamines" @default.
- W3029690841 cites W1512851684 @default.
- W3029690841 cites W1547450219 @default.
- W3029690841 cites W1573403664 @default.
- W3029690841 cites W1790240239 @default.
- W3029690841 cites W1861915930 @default.
- W3029690841 cites W1865648459 @default.
- W3029690841 cites W1869318594 @default.
- W3029690841 cites W1882149925 @default.
- W3029690841 cites W1935840505 @default.
- W3029690841 cites W1940208062 @default.
- W3029690841 cites W1949586022 @default.
- W3029690841 cites W1967584705 @default.
- W3029690841 cites W1976302032 @default.
- W3029690841 cites W1978896186 @default.
- W3029690841 cites W1987506486 @default.
- W3029690841 cites W2001101603 @default.
- W3029690841 cites W2006236831 @default.
- W3029690841 cites W2009131522 @default.
- W3029690841 cites W2009501393 @default.
- W3029690841 cites W2012804469 @default.
- W3029690841 cites W2020257768 @default.
- W3029690841 cites W2028756918 @default.
- W3029690841 cites W2030534966 @default.
- W3029690841 cites W2032766936 @default.
- W3029690841 cites W2033176002 @default.
- W3029690841 cites W2035502147 @default.
- W3029690841 cites W2040802654 @default.
- W3029690841 cites W2050564444 @default.
- W3029690841 cites W2052599602 @default.
- W3029690841 cites W2052610204 @default.
- W3029690841 cites W2053889945 @default.
- W3029690841 cites W2057499380 @default.
- W3029690841 cites W2058872318 @default.
- W3029690841 cites W2060942917 @default.
- W3029690841 cites W2061199300 @default.
- W3029690841 cites W2065638824 @default.
- W3029690841 cites W2067572945 @default.
- W3029690841 cites W2075473160 @default.
- W3029690841 cites W2078127406 @default.
- W3029690841 cites W2078707624 @default.
- W3029690841 cites W2078840603 @default.
- W3029690841 cites W2088328410 @default.
- W3029690841 cites W2089293981 @default.
- W3029690841 cites W2096153342 @default.
- W3029690841 cites W2099115964 @default.
- W3029690841 cites W2099443640 @default.
- W3029690841 cites W2107334322 @default.
- W3029690841 cites W2107455390 @default.
- W3029690841 cites W2110528006 @default.
- W3029690841 cites W2110575475 @default.
- W3029690841 cites W2114040130 @default.
- W3029690841 cites W2116286718 @default.
- W3029690841 cites W2118193517 @default.
- W3029690841 cites W2125373439 @default.
- W3029690841 cites W2126986279 @default.
- W3029690841 cites W2133063407 @default.
- W3029690841 cites W2133828007 @default.
- W3029690841 cites W2134493337 @default.
- W3029690841 cites W2134939208 @default.
- W3029690841 cites W2135221579 @default.
- W3029690841 cites W2135943092 @default.
- W3029690841 cites W2135946292 @default.
- W3029690841 cites W2140821709 @default.
- W3029690841 cites W2143759493 @default.
- W3029690841 cites W2150629018 @default.
- W3029690841 cites W2155958842 @default.
- W3029690841 cites W2156094245 @default.
- W3029690841 cites W2158175641 @default.
- W3029690841 cites W2159532100 @default.
- W3029690841 cites W2160310761 @default.
- W3029690841 cites W2160619733 @default.
- W3029690841 cites W2161074777 @default.
- W3029690841 cites W2168516002 @default.
- W3029690841 cites W2169993331 @default.
- W3029690841 cites W2171087757 @default.
- W3029690841 cites W2274176326 @default.
- W3029690841 cites W2299688666 @default.
- W3029690841 cites W2422244658 @default.
- W3029690841 cites W2490108701 @default.
- W3029690841 cites W2735798577 @default.
- W3029690841 cites W2762158227 @default.
- W3029690841 cites W2777753808 @default.
- W3029690841 cites W2886288057 @default.
- W3029690841 cites W2889788554 @default.
- W3029690841 cites W2902453263 @default.
- W3029690841 cites W2920949246 @default.
- W3029690841 cites W2947584707 @default.