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- W3029691995 abstract "目的 探讨锂盐对小鼠吗啡行为敏化的影响.方法测定小鼠的自主活动,观察锂盐对小鼠自主活动的影响.急性吗啡(10mg/kg)处理小鼠前给予锂盐,观察锂盐对急性吗啡引起小鼠自主活动的影响.慢性吗啡处理小鼠,建立吗啡行为敏化小鼠模型,观察锂盐对吗啡行为敏化的影响.结果1.锂盐(2～8mEq/kg)明显抑制小鼠的自主活动,并呈剂量依赖性.2.锂盐剂量依赖性地抑制急性吗啡所致小鼠的高活动性.3.锂盐剂量依赖性地阻断小鼠吗啡行为敏化的表达,但不影响行为敏化的形成.结论锂盐对中枢神经系统具有抑制作用,并能够抑制吗啡引起的小鼠高活动性以及行为敏化的表达,提示锂盐可能对吗啡的精神依赖性具有干预作用。" @default.
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- W3029691995 date "2004-04-20" @default.
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- W3029691995 title "Effects of lithium on morphine induced behavioral sensitization in mice" @default.
- W3029691995 doi "https://doi.org/10.3760/cma.j.issn.1005-8559.2004.02.011" @default.
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