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- W3029698977 abstract "ObjectiveTo investigate the effect of intravenous tranexamic acid (TXA) on perioperative hidden blood loss in percutaneous pedicle screw fixation for thoracolumbar fractures.MethodsA prospective study was conducted in the 113 patients who would be subjected to percutaneous pedicle screw fixation for thoracolumbar fracture from January 2017 to December 2017. They were randomly assigned into an observation group (n=58) receiving intravenous drip of 15 mg/kg TXA 30 minutes preoperation or a control group (n=55) receiving intravenous drip of normal saline solution 30 minutes preoperation. The total blood loss and hidden blood loss 24 hours postoperation, D-dimer volume, incidences of deep vein thrombosis and other complications were recorded and compared between the 2 groups.ResultsThere were 54 patients in the observation group and 50 patients in the control group for statistic analysis. The observation group had significantly less total blood loss (319.0±140.5 mL) and hidden blood loss (242.0±143.4 mL) 24 hours postoperation than the control group (418.7±188.1 mL and 354.7±181.9 mL, respectively) (P 0.05). The volume of postoperative D-dimer was significantly higher than the preoperative value in both groups (P<0.05).No thromboembolic events occurred in either group.ConclusionIntravenous TXA may significantly reduce intraoperative hidden blood loss with no increased rik of thromboembolic events in percutaneous pedicle screw fixation for thoracolumbar fractures.Key words: Tranexamic acid; Thoracic vertebrae; Lumbar vertebrae; Minimally invasive surgical procedures; Hidden blood loss" @default.
- W3029698977 created "2020-06-05" @default.
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- W3029698977 date "2018-04-15" @default.
- W3029698977 modified "2023-09-23" @default.
- W3029698977 title "Effect of intravenous tranexamic acid on perioperative hidden blood loss in percutaneous pedicle screw fixation for thoracolumbar fractures" @default.
- W3029698977 doi "https://doi.org/10.3760/cma.j.issn.1671-7600.2018.04.004" @default.
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