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- W3029705890 abstract "目的:改进大鼠短暂性(<2小时)局灶性脑缺血模型的制作方法.方法:采用雄性SD大鼠24只,分实验组和对照组,实验组又分三组,用线栓法使大脑中动脉(MCA)分别缺血15min、30min、60min,每组6只;假手术对照组6只.所有实验动物均采用乙醚麻醉,在手术过程中用5-0丝线结扎颈外动脉,在结扎的近侧剪断颈外动脉或其分支-枕动脉,经颈外动脉断端或枕动脉将4-0单丝尼龙线插入颈内动脉直至大脑中动脉起始处.假手术对照组动物线栓插入颅内但不达大脑中动脉起始处.术后即可观察动物行走时是否转圈.结果:所有实验组动物都及时观察到动物行走时出现转圈的表现,符合实验的入组标准.假手术对照组动物术后没有观察到转圈的表现.结论:短暂性局灶性脑缺血模型制作方法经改进更易于制作、可行性更强、可信度更高且有利于进一步推广运用." @default.
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- W3029705890 date "2001-03-06" @default.
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- W3029705890 title "The Modified Method of Making Transient Focal Cerebral Ischemia in Rats" @default.
- W3029705890 doi "https://doi.org/10.3969/j.issn.1671-7163.2001.01.003" @default.
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