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- W3029717781 abstract "目的 通过检测乳腺癌组织中环氧化酶-2(COX-2)表达情况并分析其与患者临床病理特征之间的关系,探讨COX-2在乳腺癌发生、发展过程中的作用.方法 应用免疫组织化学法,对乳腺癌组织40份与癌旁正常乳腺组织18份进行COX-2蛋白表达检测.结果 肿瘤组织中阳性表达率为52.50%,大多数呈中度至高度表达,癌旁组织仅少数呈低表达,阳性表达率为11.11%,两者比较差异有统计学意义(P＜0.005).且COX-2的表达与淋巴结转移、HER-2高表达情况有显著相关性(P＜0.05).而与年龄、肿瘤大小及临床分期差异均无统计学意义(P＞0.05).结论 COX-2的阳性表达与乳腺癌淋巴结转移及HER-2高表达有关,COX-2高表达可能在乳腺癌的发生、发展及预后中起着重要作用。" @default.
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- W3029717781 date "2007-05-28" @default.
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- W3029717781 title "Significance of the expression of cyclooxygenase-2 in breast cancers" @default.
- W3029717781 doi "https://doi.org/10.3760/cma.j.issn.1006-9801.2007.05.008" @default.
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