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- W3029718094 abstract "目的 探讨宫颈癌组织中人乳头状瘤病毒(HPV) 16E6 mRNA表达与survivin蛋白表达的相关性.方法采用半定量PCR技术和免疫组化链霉菌抗生物素蛋白-过氧化物酶连接法,检测慢性宫颈炎、宫颈上皮内瘤变(CIN)及宫颈癌共148例患者宫颈组织中HPV16E6 mRNA及survivin蛋白的表达.结果 148例患者中,HPV16阳性共37例,其中慢性宫颈炎5例、CINⅠ6例、CINⅡ～Ⅲ11例及宫颈癌15例.慢性宫颈炎、CINⅠ、CINⅡ～Ⅲ及宫颈癌组织中,HPV16E6 mRNA的表达水平分别为0.3±0.4、0.6±0.4、1.8±0.6及2.4±0.6;survivin蛋白阳性表达率分别为7%、31%、63%及84%.CINⅡ～Ⅲ及宫颈癌组织中,HPV16 E6 mRNA的表达水平及survivin蛋白阳性表达率均显著高于慢性宫颈炎及CINⅠ组织,两者比较,差异均有统计学意义(P<0.01).宫颈癌组织中, HPV16 E6 mRNA的表达水平与survivin蛋白阳性表达率呈显著正相关关系(γs =0.62,P<0.05).结论HPV16 E6 mRNA的表达水平与宫颈病变的进展有关,survivin蛋白阳性表达率升高可能与宫颈癌的发生、发展密切相关。" @default.
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- W3029718094 date "2005-09-18" @default.
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- W3029718094 title "Quantities of human papillomavirus 16 E6 mRNA and its relationship with expression of survivin in cervical cancer" @default.
- W3029718094 doi "https://doi.org/10.3760/j.issn:0529-567x.2005.09.013" @default.
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