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• W3029721844 abstract "ObjectiveTo explore the characteristics of impaired glucoregulation during different treatment stages in patients with Graves' disease from the coastal area of Shandong Province.MethodsA total of 106 patients with Graves' disease from Qilu Hospital of Shandong University were enrolled in this study and divided into 3 groups according to different treatment stages: primary treatment period group (GD1 group), treatment period group (GD2 group) and titration period group (GD3 group). Thirty healthy person were taken as normal control (NC group). All patients were treated by antithyroid drugs (ATD) for 6 months. On baseline and after treatment, the levels of blood glucose and serum insulin were evaluated, the values of early phase insulin secretion index (ΔI30/ΔG30), glucose area under curve (GAUC) and insulin area under curve(INSAUC) were calculated by oral glucose tolerance test(OGTT) and insulin release test(InsRT) in all patients. Data were analyzed by the one-way analysis of variance (ANOVA).ResultsThe fasting blood glucose levels were all lower in GD groups than that in NC group (F=29.85, P<0.05), on baseline; and the levels of blood glucose and insulin in GD groups after OGTT were markedly higher than those in the NC group(F=22.54, 87.96, both P<0.05). Compared with NC group, the values of ΔI30/ΔG30 in GD groups decreased significantly (F=17.22, P<0.05), however, the values of GAUC, INSAUC of GD groups increased significantly (F=79.09, 112.77, both P<0.05). After the treatment, the levels of blood glucose and insulin decreased significantly (F=17.19, 48.88, both P<0.05), the values of GAUC, INSAUC of GD groups decreased significantly(F=53.08, 96.98, both P<0.05).ConclusionsThe glucoregulation is impaired in patients with Graves' disease from the coastal area of Shandong Province. The impaired glucoregulation manifests as lower fasting blood glucose, impaired glucose tolerance and β cell dysfunction, and characterized by impaired early-phases insulin secretion and hyperinsulinemia. Normalization of thyroid function improves the impaired glucoregulation, but the dysfunction of islet βcell will last for a long period.Key words: Graves' disease; Impaired glucose regulation; Insulin secretion" @default.
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• W3029721844 date "2014-03-27" @default.
• W3029721844 modified "2023-09-23" @default.
• W3029721844 title "Characteristics of impaired glucoregulation in patients with Graves' disease from the coastal area of Shandong Province" @default.
• W3029721844 doi "https://doi.org/10.3760/cma.j.issn.1674-5809.2014.03.007" @default.
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