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- W3029744331 abstract "Objective To investigate the role of PET with 18 F-fluorodeoxyglucose (FDG) for differentiating malignant form benign lesions in the pancreas. Methods 18 F-FDG PET imaging was performed on 30 patients including 20 cases with pancreatic malignant tumors (15 adenocarcinoma,1 low malignant islet cell tumor,1 carcinosarcoma,and 3 patients with recurrent tumor after resection of primary pancreatic adenocarcinoma),and 10 cases with chronic pancreatitis (pancreatic pseudocysts were found in 3 of them). The final diagnosis was obtained by pathologic ( n = 22) and clinical or radiologic follow-up lasted 3～12 months ( n =8). PET findings were compared with the results of abdominal CT( n =25) and/or MRI( n =8) done within 2 weeks. Fasting blood sugar levels were controled in 3.9～5.9 mmol/L in all patients at first,then 222～296 MBq of 18 F-FDG was intravenously injected,the transmision and emission scan were performed 1 h after injection. The images of FDG PET were analyzed visually and semiquantitatively using standard uptake value (SUV). Results Nineteen of twenty patients with malignant tumors (95.0%) showed increased FDG uptake with a SUV of 4.91±3.65,and 9 of 10 patients with chronic pancreatitis (90%) showed low FDG uptake with a SUV of 1.70±1.12 ( t =2.69,P =0.0120.05). There was 1 false-positive PET (pancreatic pseudocyst,SUV 4.82)and 1 false-negative PET (recurrent adenocarcinoma,SUV 2.1). Tumors ≤3 cm in diameter were of SUV of 2.75±0.63( n =4),3.1～5 cm,of SUV of 4.59±3.06( n =6),and 5 cm,of SUV of 5.46±2.29( n =10,χ 2=9.02,P =0.011). Using a cut-off value of 2.5 for the SUV,the sensitivity,specificity and accuracy for diagnosing pancreatic malignant tumors using FDG PET were higher than that of abdominal CT (95.0%,90.0% and 93.3% versus 75.0%,55.6% and 68.0%,respectively,χ 2=5.89,P =0.015). Conclusion 18 F-FDG PET is a sensitive and specific noninvasive technique for diagnosing pancreatic disorders." @default.
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- W3029744331 date "2004-02-25" @default.
- W3029744331 modified "2023-09-23" @default.
- W3029744331 title "The role of ~(18)F-FDG PET for differentiating malignant from benign lesions in the pancreas" @default.
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