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- W3029746129 abstract "Objective To investigate the imaging characteristics and diagnostic criteria of 18FFDG brain PET in diagnosis of Alzheimer's disease (AD). Methods The study included 12 normal subjects, 12 patients with AD and 11 patients with nonAD dementia. 40 min after intravenous administration of 18FFDG, brain scan was performed using Siemens ECAT 47 scanner. The transaxial, coronal and sagittal images were then reconstructed by computer. At the same time, semiquantitative analysis was also applied to help evaluation using the ratio of mean radioactivity of cerebral lobe to cerebellum (Rcl/cb). Results In normal subjects PET scan showed clear images of cerebral cortex, basal ganglia, thalamus and cerebellum with symmetrical distribution of radioactivity. PET images from Alzheimer's disease patients were classified into 3 patterns: bilateral parietal hypometabolism in 5 cases, bilateral temporoparietal hypometabolism in 4 cases and unilateral temporoparietal hypometabolism in 3 cases. The Rcl/cb of AD patients in parietal and temporal lobe was significantly decreased than normal subjects (P<0.05). PET images from nonAD dementia were also classified into 3 patterns; multiple and asymmetrical patch foci with decreased radioactivity in 8 cases, bilateral temporoparietal with diffuse cortical hypometabolism in 2 cases, and normal imaging in 1 case. The hypometabolic involvement was found in accord with severity of dementia. The Rcl/cb was also reflecting the dementia degree. Compared with MRI imaging, 12 patients with AD had cerebral hypometabolism but only 10 had hippocampus atrophy. 10 patients with nonAD dementia had local structural foci seen in MRI, including old hemorrhage, infarction and encephalomalacia, but these lesions were not found in AD. Conclusions Based on excluding cerebral structural lesions which are better detected by MRI, bilateral or unilateral parietal or temporoparietal hypometabolism found in FDG PET can be considered indicative of Alzheimer's disease. Semiquantitative analysis of the images yielded can help to evaluate the dementia degree.Key words: Dementia, senile; Tomography, emissioncomputed; Deoxyglucose" @default.
- W3029746129 created "2020-06-05" @default.
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- W3029746129 date "2000-03-25" @default.
- W3029746129 modified "2023-09-24" @default.
- W3029746129 title "The preliminary study of 18F-FDG brain PET in diagnosis of Alzheimer's Disease" @default.
- W3029746129 doi "https://doi.org/10.3760/cma.j.issn.0253-9780.2000.02.002" @default.
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