FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029782578> ?p ?o ?g. }

• W3029782578 endingPage "187" @default.
• W3029782578 startingPage "183" @default.
• W3029782578 abstract "Objective To evaluate the efficacy of small dosage dexamethasone therapy in chronic viral hepatitis B patients with tendency to severe hepatitis.Methods Sixty cases of chronic hepatitis B patients with tendency to severe hepatitis in the Third Affiliated Hospital of Sun Yat-sen University from July 2010 to November 2011 were randomly divided into the treatment group (n =30) and control group (n =30).The control group received comprehensive physical treatment and antiviral treatment with entecavir,while the treatment group was treated with dexamethasone therapy (10 mg/d,3 days,intravenous injection) on the basis of the above mentioned treatment.The serum alanine transaminase (ALT),total bilirubine (TBil),prothrombin time (PT),clinical improvement rate and hospitalization time between the two groups were compared during therapy at weeks 0,1,4,8,10 and 12.Results The serum ALT levels on admission were (561.6 ± 425.1) and (576.8 ± 437.8) U/L respectively.There were no significant statistical differences between the two groups(t =-0.36,P ＞ 0.05).After the treatment,ALT levels in two groups decreased with time.ALT in treatment group were all lower than control group from week 1 to week 10.However,at week 12,the serum ALT levels in 2 groups were(38.9 ± 10.9) and (40.6 ± 11.3) U/L respectively.There were no significant statistical differences between the two groups(t =-0.13,P ＞ 0.05).Compared to the control group,TBil decreased and PT shortened significantly in treatment group patients after therapy for 12 weeks.The serum TBil in treatment group at weeks 1,2,4,8,10 and 12 were (449.2± 185.3),(350.1 ± 194.8),(235.6±91.6),(189.6±64.7),(120.8± 56.9) and (74.6± 32.8) μmol/L,and were lower than control group (t =-7.20,-12.97,-17.52,-14.80,-11.60 and-10.71,P ＜ 0.05).The PT in treatment group at weeks 1,2,4,8,10 and 12 were(40.2 ± 6.7),(30.3 ± 10.6),(27.3 ± 5.9),(22.3 ± 6.4),(19.4 ± 6.5)and (17.3 ± 7.5)s,and were higher than control group (t =-6.05,-6.68,-8.48,-10.28,-6.60 and-4.69,P ＜0.05).The improvement rate in treatment group was higher than control group (86.7％:43.3％,x2 =0.02,P ＜0.05).The average hospitalization time in treatment group was shorter than control group(32.1 d vs 79.7 d,t =-17.27,P ＜ 0.05).Conclusions Short-term dexamethasone therapy in chronic hepatitis B patients with tendency to severe hepatitis can improve liver function,the clinical improvement rate and shorten the hospitalization time.Key words: Hepatitis B; Severe hepatitis; Glucocorticoid" @default.
• W3029782578 created "2020-06-05" @default.
• W3029782578 creator A5009147506 @default.
• W3029782578 creator A5054545180 @default.
• W3029782578 creator A5063263180 @default.
• W3029782578 date "2013-06-25" @default.
• W3029782578 modified "2023-09-24" @default.
• W3029782578 title "The short-term efficacy of small dosage of dexamethasone therapy in chronic hepatitis B with tendency to severe hepatitis" @default.
• W3029782578 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2013.03.011" @default.
• W3029782578 hasPublicationYear "2013" @default.
• W3029782578 type Work @default.
• W3029782578 sameAs 3029782578 @default.
• W3029782578 citedByCount "0" @default.
• W3029782578 crossrefType "journal-article" @default.
• W3029782578 hasAuthorship W3029782578A5009147506 @default.
• W3029782578 hasAuthorship W3029782578A5054545180 @default.
• W3029782578 hasAuthorship W3029782578A5063263180 @default.
• W3029782578 hasConcept C126322002 @default.
• W3029782578 hasConcept C181199279 @default.
• W3029782578 hasConcept C185592680 @default.
• W3029782578 hasConcept C203014093 @default.
• W3029782578 hasConcept C2522874641 @default.
• W3029782578 hasConcept C2776029263 @default.
• W3029782578 hasConcept C2776175608 @default.
• W3029782578 hasConcept C2776877979 @default.
• W3029782578 hasConcept C2777382497 @default.
• W3029782578 hasConcept C2777869810 @default.
• W3029782578 hasConcept C2778606649 @default.
• W3029782578 hasConcept C2780401358 @default.
• W3029782578 hasConcept C2780434524 @default.
• W3029782578 hasConcept C3019983190 @default.
• W3029782578 hasConcept C3020491458 @default.
• W3029782578 hasConcept C55493867 @default.
• W3029782578 hasConcept C71924100 @default.
• W3029782578 hasConcept C90924648 @default.
• W3029782578 hasConceptScore W3029782578C126322002 @default.
• W3029782578 hasConceptScore W3029782578C181199279 @default.
• W3029782578 hasConceptScore W3029782578C185592680 @default.
• W3029782578 hasConceptScore W3029782578C203014093 @default.
• W3029782578 hasConceptScore W3029782578C2522874641 @default.
• W3029782578 hasConceptScore W3029782578C2776029263 @default.
• W3029782578 hasConceptScore W3029782578C2776175608 @default.
• W3029782578 hasConceptScore W3029782578C2776877979 @default.
• W3029782578 hasConceptScore W3029782578C2777382497 @default.
• W3029782578 hasConceptScore W3029782578C2777869810 @default.
• W3029782578 hasConceptScore W3029782578C2778606649 @default.
• W3029782578 hasConceptScore W3029782578C2780401358 @default.
• W3029782578 hasConceptScore W3029782578C2780434524 @default.
• W3029782578 hasConceptScore W3029782578C3019983190 @default.
• W3029782578 hasConceptScore W3029782578C3020491458 @default.
• W3029782578 hasConceptScore W3029782578C55493867 @default.
• W3029782578 hasConceptScore W3029782578C71924100 @default.
• W3029782578 hasConceptScore W3029782578C90924648 @default.
• W3029782578 hasIssue "03" @default.
• W3029782578 hasLocation W30297825781 @default.
• W3029782578 hasOpenAccess W3029782578 @default.
• W3029782578 hasPrimaryLocation W30297825781 @default.
• W3029782578 hasRelatedWork W2348728863 @default.
• W3029782578 hasRelatedWork W2348992910 @default.
• W3029782578 hasRelatedWork W2352473928 @default.
• W3029782578 hasRelatedWork W2354709356 @default.
• W3029782578 hasRelatedWork W2360243692 @default.
• W3029782578 hasRelatedWork W2360301968 @default.
• W3029782578 hasRelatedWork W2363727978 @default.
• W3029782578 hasRelatedWork W2363862310 @default.
• W3029782578 hasRelatedWork W2365749321 @default.
• W3029782578 hasRelatedWork W2367394009 @default.
• W3029782578 hasRelatedWork W2367527411 @default.
• W3029782578 hasRelatedWork W2370982865 @default.
• W3029782578 hasRelatedWork W2372967237 @default.
• W3029782578 hasRelatedWork W2374552332 @default.
• W3029782578 hasRelatedWork W2378732154 @default.
• W3029782578 hasRelatedWork W2384906159 @default.
• W3029782578 hasRelatedWork W2390715376 @default.
• W3029782578 hasRelatedWork W2391380242 @default.
• W3029782578 hasRelatedWork W3028596839 @default.
• W3029782578 hasRelatedWork W3032507643 @default.
• W3029782578 hasVolume "40" @default.
• W3029782578 isParatext "false" @default.
• W3029782578 isRetracted "false" @default.
• W3029782578 magId "3029782578" @default.
• W3029782578 workType "article" @default.