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- W3029791388 abstract "Chronic obstructive pulmonary disease(COPD) is a pulmonary disease by persistent airflow limitation which showing progressive development and can be prevented.Hypoxia is common complication of COPD because of diminished respiratory function.Hypoxia-induced factor(HIF) is a nuclear transcription factor that plays an important role in hypoxic state.However, the compensatory function of hypoxia was mediated by HIF while causing pathological damage, such as hypoxic pulmonary hypertension and tumor.Prolyl hydroxylase (PHDs) is the real trigger of hypoxic reaction which can directly control the HIF by prompted the hydroxylation of HIF.To some extent, PHDs will prevent the complications of COPD include pulmonary hypertension and lung cancer.Key words: Chronic obstructive pulmonary disease; Hypoxia-induced factor; Prolyl hydroxylase; Pulmonary hypertension; Cancer" @default.
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- W3029791388 date "2016-10-05" @default.
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- W3029791388 title "The expression and clinical significance of PHDs and HIF in patient with COPD" @default.
- W3029791388 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2016.19.010" @default.
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