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- W3029810013 abstract "Adipose tissue not only can store excess energy, but also serves as an active endocrine organ secreting a variety of bioactive substances, such as leptin and adiponectin. These substances are called adipokines, and are important mediators of the interaction between host nutritional status and the neuroendocrine-immune system. Adipocytes and macrophages both participate in the release of proinflammatory cytokines, such as tumor necrosis factor (TNF), interleukin-6(IL-6), IL-8, monocyte chemotactic protein-1 (MCP-1)and adipokines (including adiponectin, leptin, resistin, and so on). Adiponectin is not only closely associated with obesity and insulin resistance, but also has anti-inflammatory and vascular protective effects. Some cytokines such as TNF-α and IL-6 can inhibit the expression of adiponectin in vitro, while adiponectin can suppress the secretion of TNF-α, IL-6, IL-17, IL-22 and interferon γ by keratinocytes and T lymphocytes. The level of adiponectin is negatively correlated with the severity of psoriasis as well as levels of TNF-α and IL-6.Key words: Psoriasis; Adiponectin; Receptors, adiponectin; Adipokines; Signal transduction" @default.
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- W3029810013 date "2016-07-15" @default.
- W3029810013 modified "2023-09-25" @default.
- W3029810013 title "Adiponectin and its correlation with psoriasis" @default.
- W3029810013 doi "https://doi.org/10.3760/cma.j.issn.1673-4173.2016.04.007" @default.
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