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- W3029828497 abstract "Metals have important roles in biological systems due to their essential or toxic character, the participation in controlling numerous cellular and biological processes, and their effects on the metabolism that regulates numerous cellular processes. The study of metal-induced changes on metabolic pathways is fundamental to decipher the biological response related to environmental problems. In this context, the omics, such as metallomics and metabolomics, are powerful methodological tools to reach this aim by searching for biomarkers that act as a warning of harmful environmental situations. Generally, different bioindicator organisms (mice, clams, and crabs) have been used to evaluate the biological response associated with the presence of contaminants in the laboratory, which can be extrapolated to actual environmental issues in terrestrial and aquatic systems. Suitable exposure experiments and the application of multidimensional analytical techniques based on the coupling of chromatography with inductively coupled plasma mass spectrometry for very specific analysis of metal-containing biomolecules (metallomics), as well as the use of organic mass spectrometry, are considered for the nontargeted evaluation of metabolite changes caused by the contamination (metabolomics). Translational application of this methodology to natural spaces affected by contamination allows establishing, in a closer evaluation, the processes involved in the environment degradation and its assessment." @default.
- W3029828497 created "2020-06-05" @default.
- W3029828497 creator A5011175306 @default.
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- W3029828497 date "2020-01-01" @default.
- W3029828497 modified "2023-10-17" @default.
- W3029828497 title "Environmental metallomics and metabolomics in free-living and model organisms" @default.
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