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• W3029837119 endingPage "2329" @default.
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• W3029837119 abstract "Abstract Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)‐to‐Purkinje cell (PC) synapse provides a suitable model to study pruning and pruning‐relevant processes during early postnatal development. Until now, the role of microglia in pruning remains under intense investigation. Here, we analyzed migration of microglia into the cerebellar cortex during early postnatal development and their possible contribution to the elimination of CF‐to‐PC synapses. Microglia enrich in the PC layer at pruning‐relevant time points giving rise to the possibility that microglia are actively involved in synaptic pruning. We investigated the contribution of microglial fractalkine (CX 3 CR1) signaling during postnatal development using genetic ablation of the CX 3 CR1 receptor and an in‐depth histological analysis of the cerebellar cortex. We found an aberrant migration of microglia into the granule and the molecular layer. By electrophysiological analysis, we show that defective fractalkine signaling and the associated migration deficits neither affect the pruning of excess CFs nor the development of functional parallel fiber and inhibitory synapses with PCs. These findings indicate that CX 3 CR1 signaling is not mandatory for correct cerebellar circuit formation. Main Points Ablation of CX 3 CR1 results in a transient migration defect in cerebellar microglia. CX 3 CR1 is not required for functional pruning of cerebellar climbing fibers. Functional inhibitory and parallel fiber synapse development with Purkinje cells is undisturbed in CX 3 CR1‐deficient mice." @default.
• W3029837119 created "2020-06-05" @default.
• W3029837119 creator A5019697934 @default.
• W3029837119 creator A5022920379 @default.
• W3029837119 creator A5034248779 @default.
• W3029837119 creator A5052087002 @default.
• W3029837119 creator A5055837807 @default.
• W3029837119 date "2020-06-02" @default.
• W3029837119 modified "2023-10-15" @default.
• W3029837119 title "Undisturbed climbing fiber pruning in the cerebellar cortex of <scp>CX₃CR1</scp>‐deficient mice" @default.
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• W3029837119 doi "https://doi.org/10.1002/glia.23842" @default.
• W3029837119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32488990" @default.
• W3029837119 hasPublicationYear "2020" @default.
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• W3029837119 hasAuthorship W3029837119A5019697934 @default.
• W3029837119 hasAuthorship W3029837119A5022920379 @default.

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