Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029846969> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3029846969 endingPage "1940" @default.
- W3029846969 startingPage "1939" @default.
- W3029846969 abstract "Objective To investigate the function of cisplatin combined with Zoledronic acid on proliferation and mechanisms of A549 cells.Methods ( 1 ) Methyl thiazol tetrazolium (MTT) assay and Annexin V-FITC/PI double-staining flow cytometry were employed to observe the effects of cisplatin combined with Zoledronic acid upon anti-proliferation and apoptosis respectively.Reverse transcription-polymerase chain reaction (RT-PCR) was applied to assay mRNA expression of MDC1 among different groups.Results Inhibition of the cell proliferation was observed under the treatment of combined cisplatin and zoledronic acid (39.16 ±4.94)％,superior to the treatment of zoledronic acid ( 19.66 ±4.57)％ or cisplatin ( 16.87 ± 2.50) ％.Combined group induced A549 cells apoptosis ( 32.30 ± O.50 ) ％,compared with cisplatin (23.90 ± 2.46) ％,zoledronic acid ( 18.87 ± 3.04 ) ％,the difference was statistically significant; cisplatin after zoledronic acid treatment of A549 cells M DC1 mRNA expression (0.134 ± 0.037 )was significantly decreased compared with single-drug,zoledronic acid ( 0.208 ± 0.040 ) and cisplatin (0.356 ± 0.033) ( P ＜ 0.05 ).Conclusion Zoledronic acid or cisplatin can significantly inhibit A549 cell proliferation and markedly induce the apoptosis.Zoledronic acid and cisplatin in a synergistic way inhibited the cell proliferation and induced apoptosis on A549 cell.The downregulated expression level of MDC1 mRNA may involved in the mechanism of synergistic effect.Key words: Lung Cancer; Cisplatin; Zoledronic acid; A549 cell line; MDC1" @default.
- W3029846969 created "2020-06-05" @default.
- W3029846969 creator A5008924675 @default.
- W3029846969 creator A5047506621 @default.
- W3029846969 creator A5073675400 @default.
- W3029846969 creator A5086154174 @default.
- W3029846969 date "2011-11-08" @default.
- W3029846969 modified "2023-09-24" @default.
- W3029846969 title "Mechanism of cisplatin combined with zoledronic acid on lung cancer A549 cells" @default.
- W3029846969 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2011.11.042" @default.
- W3029846969 hasPublicationYear "2011" @default.
- W3029846969 type Work @default.
- W3029846969 sameAs 3029846969 @default.
- W3029846969 citedByCount "0" @default.
- W3029846969 crossrefType "journal-article" @default.
- W3029846969 hasAuthorship W3029846969A5008924675 @default.
- W3029846969 hasAuthorship W3029846969A5047506621 @default.
- W3029846969 hasAuthorship W3029846969A5073675400 @default.
- W3029846969 hasAuthorship W3029846969A5086154174 @default.
- W3029846969 hasConcept C126322002 @default.
- W3029846969 hasConcept C143998085 @default.
- W3029846969 hasConcept C153911025 @default.
- W3029846969 hasConcept C185592680 @default.
- W3029846969 hasConcept C190283241 @default.
- W3029846969 hasConcept C2776326535 @default.
- W3029846969 hasConcept C2776694085 @default.
- W3029846969 hasConcept C2778239845 @default.
- W3029846969 hasConcept C2780783641 @default.
- W3029846969 hasConcept C502942594 @default.
- W3029846969 hasConcept C55493867 @default.
- W3029846969 hasConcept C62112901 @default.
- W3029846969 hasConcept C71924100 @default.
- W3029846969 hasConcept C81729549 @default.
- W3029846969 hasConcept C86803240 @default.
- W3029846969 hasConceptScore W3029846969C126322002 @default.
- W3029846969 hasConceptScore W3029846969C143998085 @default.
- W3029846969 hasConceptScore W3029846969C153911025 @default.
- W3029846969 hasConceptScore W3029846969C185592680 @default.
- W3029846969 hasConceptScore W3029846969C190283241 @default.
- W3029846969 hasConceptScore W3029846969C2776326535 @default.
- W3029846969 hasConceptScore W3029846969C2776694085 @default.
- W3029846969 hasConceptScore W3029846969C2778239845 @default.
- W3029846969 hasConceptScore W3029846969C2780783641 @default.
- W3029846969 hasConceptScore W3029846969C502942594 @default.
- W3029846969 hasConceptScore W3029846969C55493867 @default.
- W3029846969 hasConceptScore W3029846969C62112901 @default.
- W3029846969 hasConceptScore W3029846969C71924100 @default.
- W3029846969 hasConceptScore W3029846969C81729549 @default.
- W3029846969 hasConceptScore W3029846969C86803240 @default.
- W3029846969 hasIssue "11" @default.
- W3029846969 hasLocation W30298469691 @default.
- W3029846969 hasOpenAccess W3029846969 @default.
- W3029846969 hasPrimaryLocation W30298469691 @default.
- W3029846969 hasRelatedWork W1501122410 @default.
- W3029846969 hasRelatedWork W2133838296 @default.
- W3029846969 hasRelatedWork W2135556747 @default.
- W3029846969 hasRelatedWork W2340909624 @default.
- W3029846969 hasRelatedWork W2348510008 @default.
- W3029846969 hasRelatedWork W2350325646 @default.
- W3029846969 hasRelatedWork W2355757563 @default.
- W3029846969 hasRelatedWork W2356364449 @default.
- W3029846969 hasRelatedWork W2360110374 @default.
- W3029846969 hasRelatedWork W2362727917 @default.
- W3029846969 hasRelatedWork W2364372875 @default.
- W3029846969 hasRelatedWork W2369079903 @default.
- W3029846969 hasRelatedWork W2376956313 @default.
- W3029846969 hasRelatedWork W2377059497 @default.
- W3029846969 hasRelatedWork W2385505470 @default.
- W3029846969 hasRelatedWork W2388177768 @default.
- W3029846969 hasRelatedWork W2418623306 @default.
- W3029846969 hasRelatedWork W2978974309 @default.
- W3029846969 hasRelatedWork W3032430862 @default.
- W3029846969 hasRelatedWork W3145226699 @default.
- W3029846969 hasVolume "28" @default.
- W3029846969 isParatext "false" @default.
- W3029846969 isRetracted "false" @default.
- W3029846969 magId "3029846969" @default.
- W3029846969 workType "article" @default.