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- W3029852736 abstract "The essential factors of bone tissue engineering include seed cell, growth factor and scaffold material. The biological structure, biological function and preparation method of scaffold material, which is the key component in bone tissue engineering, have attracted our attention. An ideal scaffold material needs to have adequate mechanical strength, appropriate degradation speed, good biocompatibility, satisfactory availability, low price, et al. Common scaffold materials in bone tissue engineering mainly consist of inorganic matter, organic matter and natural derivatives. Silk fibroin which is extracted from silkworm protein fiber contains 18 kinds of amino acids. The glycine, alanine, serine are the main types in silk fibroin and its structure consisted of hydrogen bonding, hydrophobic bonding and crystalline region. Those special structures make it has good flexibility and tensile strength. Silk fibroin has other advantages incluing air permeability, moisture permeability and biodegradation. Besides silk fibroin with curing crystallization of diversification that easy to maintain biological affinity and form a special porous structure. Silk fibroin has good film and gel forming ability. Silk fibroin can bond with some other materials to further improve its physical and chemical properties. Silk fibroin can be formed into porous shape, membranous, gel and composite materials scaffold. The materials scaffold which based on silk fibroin has excellent mechanical performance, adjustable degradation speed, high biocompatibility and good osteogenesis performance, besides capability of loading cells, bioactive factors and drugs. In addition, silk fibroin which can be made into gel scaffold,porous scaffold,electrospinning fiber,and compound scaffold et al has three-dimensional porous and biological function for bone tissue engineering as a new choice and application prospect." @default.
- W3029852736 created "2020-06-05" @default.
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- W3029852736 date "2016-07-16" @default.
- W3029852736 modified "2023-09-23" @default.
- W3029852736 title "Synthesis and application progression of silk fibroin scaffold in bone tissue engineering" @default.
- W3029852736 doi "https://doi.org/10.3760/cma.j.issn.0253-2352.2016.14.008" @default.
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