Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029870743> ?p ?o ?g. }
- W3029870743 endingPage "862" @default.
- W3029870743 startingPage "862" @default.
- W3029870743 abstract "Studies have observed that restraint stress (RS) and the associated elevation in corticotrophin-releasing hormone (CRH) impair oocyte competence by triggering apoptosis of ovarian cells but the underlying mechanisms are largely unclear. Although one study demonstrated that RS and CRH elevation triggered apoptosis in ovarian cells and oocytes via activating Fas/FasL signalling, other studies suggested that RS might damage cells by activating other pathways as well as Fas signalling. The objective of this study was to test whether RS and CRH elevation impairs oocytes by activating tumour necrosis factor α (TNF-α) signalling. Our invivo experiments showed that RS applied during oocyte prematuration significantly increased expression of TNF-α and its receptor (TNFR1) while inducing apoptosis in both oocytes and mural granulosa cells (MGCs). Invitro treatment of MGCs with CRH significantly increased their apoptotic percentages and levels of TNF-α and TNFR1 expression. Invitro knockdown by interfering RNA, invivo knockout of the TNF-α gene or injection of TNF-α antagonist etanercept significantly relieved the adverse effects of RS and CRH on apoptosis of MGCs and/or the developmental potential and apoptosis of oocytes. The results suggest that RS and CRH elevation in females impair oocyte competence through activating TNF-α signalling and that a TNF-α antagonist might be adopted to ameliorate the adverse effects of psychological stress on oocytes." @default.
- W3029870743 created "2020-06-05" @default.
- W3029870743 creator A5000223104 @default.
- W3029870743 creator A5007316183 @default.
- W3029870743 creator A5010347728 @default.
- W3029870743 creator A5021393404 @default.
- W3029870743 creator A5053204257 @default.
- W3029870743 creator A5053816661 @default.
- W3029870743 creator A5058807153 @default.
- W3029870743 creator A5060123236 @default.
- W3029870743 date "2020-01-01" @default.
- W3029870743 modified "2023-10-03" @default.
- W3029870743 title "Restraint stress and elevation of corticotrophin-releasing hormone in female mice impair oocyte competence through activation of the tumour necrosis factor α (TNF-α) system" @default.
- W3029870743 cites W1597642552 @default.
- W3029870743 cites W1975218744 @default.
- W3029870743 cites W1980863719 @default.
- W3029870743 cites W1982596294 @default.
- W3029870743 cites W1987469498 @default.
- W3029870743 cites W1997990909 @default.
- W3029870743 cites W2000719389 @default.
- W3029870743 cites W2035104435 @default.
- W3029870743 cites W2040201685 @default.
- W3029870743 cites W2053571583 @default.
- W3029870743 cites W2054355304 @default.
- W3029870743 cites W2054483041 @default.
- W3029870743 cites W2065300349 @default.
- W3029870743 cites W2066901264 @default.
- W3029870743 cites W2074226176 @default.
- W3029870743 cites W2074405639 @default.
- W3029870743 cites W2085457548 @default.
- W3029870743 cites W2092299372 @default.
- W3029870743 cites W2097718857 @default.
- W3029870743 cites W2102618234 @default.
- W3029870743 cites W2107641986 @default.
- W3029870743 cites W2109129651 @default.
- W3029870743 cites W2114847521 @default.
- W3029870743 cites W2116326674 @default.
- W3029870743 cites W2129930491 @default.
- W3029870743 cites W2150388735 @default.
- W3029870743 cites W2150900198 @default.
- W3029870743 cites W2151323225 @default.
- W3029870743 cites W2255265887 @default.
- W3029870743 cites W2461389374 @default.
- W3029870743 cites W2491109187 @default.
- W3029870743 cites W2769941475 @default.
- W3029870743 cites W2801667090 @default.
- W3029870743 cites W2883881857 @default.
- W3029870743 cites W2937760536 @default.
- W3029870743 cites W2951170265 @default.
- W3029870743 cites W2974899930 @default.
- W3029870743 doi "https://doi.org/10.1071/rd20002" @default.
- W3029870743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32527376" @default.
- W3029870743 hasPublicationYear "2020" @default.
- W3029870743 type Work @default.
- W3029870743 sameAs 3029870743 @default.
- W3029870743 citedByCount "9" @default.
- W3029870743 countsByYear W30298707432020 @default.
- W3029870743 countsByYear W30298707432021 @default.
- W3029870743 countsByYear W30298707432022 @default.
- W3029870743 countsByYear W30298707432023 @default.
- W3029870743 crossrefType "journal-article" @default.
- W3029870743 hasAuthorship W3029870743A5000223104 @default.
- W3029870743 hasAuthorship W3029870743A5007316183 @default.
- W3029870743 hasAuthorship W3029870743A5010347728 @default.
- W3029870743 hasAuthorship W3029870743A5021393404 @default.
- W3029870743 hasAuthorship W3029870743A5053204257 @default.
- W3029870743 hasAuthorship W3029870743A5053816661 @default.
- W3029870743 hasAuthorship W3029870743A5058807153 @default.
- W3029870743 hasAuthorship W3029870743A5060123236 @default.
- W3029870743 hasConcept C126322002 @default.
- W3029870743 hasConcept C134018914 @default.
- W3029870743 hasConcept C150903083 @default.
- W3029870743 hasConcept C173396325 @default.
- W3029870743 hasConcept C17991360 @default.
- W3029870743 hasConcept C190283241 @default.
- W3029870743 hasConcept C196843134 @default.
- W3029870743 hasConcept C207001950 @default.
- W3029870743 hasConcept C2776690073 @default.
- W3029870743 hasConcept C31573885 @default.
- W3029870743 hasConcept C55493867 @default.
- W3029870743 hasConcept C66008609 @default.
- W3029870743 hasConcept C71924100 @default.
- W3029870743 hasConcept C86803240 @default.
- W3029870743 hasConcept C95444343 @default.
- W3029870743 hasConceptScore W3029870743C126322002 @default.
- W3029870743 hasConceptScore W3029870743C134018914 @default.
- W3029870743 hasConceptScore W3029870743C150903083 @default.
- W3029870743 hasConceptScore W3029870743C173396325 @default.
- W3029870743 hasConceptScore W3029870743C17991360 @default.
- W3029870743 hasConceptScore W3029870743C190283241 @default.
- W3029870743 hasConceptScore W3029870743C196843134 @default.
- W3029870743 hasConceptScore W3029870743C207001950 @default.
- W3029870743 hasConceptScore W3029870743C2776690073 @default.
- W3029870743 hasConceptScore W3029870743C31573885 @default.
- W3029870743 hasConceptScore W3029870743C55493867 @default.
- W3029870743 hasConceptScore W3029870743C66008609 @default.
- W3029870743 hasConceptScore W3029870743C71924100 @default.
- W3029870743 hasConceptScore W3029870743C86803240 @default.