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- W3029875619 abstract "Objective To evaluate the effects caused by different doses of N-nitrosodiethylamine (DENA) on establishment of a multistep carcinogenesis model of liver cirrhosis in SD rats.Methods Fifty male SD rats were randomly divided into control group (n =5 ) and experimental group (n =45 ).Experimental group consisted of 3 subgroups (high,median and low dose group ),which were intragastrically induced DENA once a week for 10 weeks,by using 70,50,35 mg/kg DENA solution,respectively.MRI was performed for inspecting pathological changes of rat livers in the following weeks.The mortality rates of different groups were calculated.The differences of the incidence of dysplastic nodule (DN) found in three groups were analyzed with Pearson Chi-square test.Results The multistep carcinogenesis development from regenerative nodule (RN) to DN to hepatocellular carcinoma (HCC) was showed in the SD rat model.Two rats in median dose group and 4 rats in high dose group died.The incidence of DNs found in 3 different groups was 20.7％ ( 6/29 ),30.6％ ( 19/62 ),14.3％ (9/63),respectively,which showed no significant difference among three groups(x2 =4.901,P ＞ 0.05).However,significant difference existed between median and high dose group( x2 =4.811,P ＜ 0.05 ).Combined with the MRI presentation,the intragastric dose of 50 mg/kg could be more appropriate among three different doses.Conclusions The median dose DENA could induce an ideal multistep carcinogenesis model of HCC which is suitable for investigating DN on MRI.Key words: Liver neoplasms, experimental; Models, animal; Rats, Sprague-Dawley" @default.
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- W3029875619 date "2012-01-10" @default.
- W3029875619 modified "2023-09-24" @default.
- W3029875619 title "Evaluation of the effects caused by different doses of N-nitrosodiethylamine on establishing multistep carcinogenesis model of cirrhotic liver in rats" @default.
- W3029875619 doi "https://doi.org/10.3760/cma.j.issn.1005-1201.2012.01.019" @default.
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