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- W3029895661 abstract "Neuronal apoptosis is one of the important forms of neuronal death in ischemic stroke. N-methyl-D-aspartate （NMDA） receptor-mediated excitatory amino acid toxicity plays an important role in neuronal apoptosis. It is the initiator and executor of apoptosis in neuronal cells. NR2B is the major regulatory subunit of this receptor, its transmembrane segment M2 is a reflexed membrane loop region facing cytoplast toward intramernbrane, forming the inner wall of ion channel, which determines the permeability of the NMDA receptor ion channel to calcium. Glutamate mediates cell injury mainly through calcium overload, therefore, NR2B subunit plays a vital role in the neuronal apoptosis in ischemic stroke.Key words: Receptors, N-methyl-D-aspartate; Protein suburlits; NR2B NMDA receptor; Apoptosis; Neurons; Neuroprotective agents" @default.
- W3029895661 created "2020-06-05" @default.
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- W3029895661 date "2010-04-15" @default.
- W3029895661 modified "2023-09-23" @default.
- W3029895661 title "N-methyl-D-aspartate receptor NR2B submit and neuronal apoptosis" @default.
- W3029895661 doi "https://doi.org/10.3760/cma.j.issn.1673-4165.2010.04.014" @default.
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