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- W3029898085 abstract "Different regulation of pituitary and adrenal gland activation leads to the dissociation of plasma adrenocorticotropic hormone and corticosteroid secretion.An increasing number of preclinical and clinical studies report dissociation of adrenocorticotropic hormone and cortisol levels in critical illness,inflammarion and mental disorders.Mechanisms involve an altered adrenal sensitivity,aberrant receptor expression or modulation of adrenal function by cytokines,vasoactive factors or neuropeptides.The degree of dissociation has been associated with the level of complications of sepsis,surgery,malignant disease and depression.The separation of adrenocorticotropic hormone and corticosteroid secretion is of clinical relevance and should be incorporated into our view on endocrine stress regulation.Key words: Adrenocorticotropic hormone; Glucocorticoids; Pituitary; Adrenal" @default.
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- W3029898085 date "2009-05-20" @default.
- W3029898085 modified "2023-09-24" @default.
- W3029898085 title "Dissociation of ACTH and glucocorticoids" @default.
- W3029898085 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2009.03.016" @default.
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