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- W3029900321 abstract "ObjectiveTo investigate the optimal treatment strategy for primary tracheal adenoid cystic carcinoma(ACC).MethodsThe clinical data of patients with primary tracheal ACC treated between January 1995 and December 2014 in Shanghai Chest Hospital were retrospectively analyzed. Cox multivariate analysis was adopted to investigate the influencing factors of overall survival and disease-free survival in patients with ACC.ResultsA total of 109 patients were identified, including 53 males and 56 females with an average age of (46.9±9.0) years (median 46 years, range 21-71 years). The mean resected tumor size and tracheal length were (28.9±7.4) mm and (32.9±7.4) mm, respectively. Patients with microscopically positive margin accounted for 84.4% (92/109). Five and 10 years overall survival (OS) and disease-free survival (DFS) were 88.7% and 43.2%, and 62.0% and 20.0%, respectively. The overall survival in patients with negative incision margin and no postoperative radiotherapy(R0/0) was significantly higher than that in patients with positive incision margin and postoperative radiotherapy(R1/1) and that in patients with positive incision margin and no postoperative radiotherapy(R1/0)(χ2=4.410, P=0.036; χ2=8.448, P=0.004). However, there was no significant difference in overall survival between R1/1 group and R1/0 group (χ2=1.690, P=0.194). The disease-free survival in R0/0 group and R1/1 group was significantly higher than that in group R1/0 (χ2=1.690, P=0.005; χ2=9.907 P=0.002), while there was no significant difference between R0/0 group and R1/1 group (χ2=2.210, P=0.137).ConclusionsR1 resection and postoperative radiotherapy can yield favorable outcomes of tracheal ACC, which can serve as the optimal regimen for this disease.Key words: Tracheal adenoid cystic carcinoma; Surgery; Margin; Radiotherapy; Survival" @default.
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- W3029900321 date "2015-08-28" @default.
- W3029900321 modified "2023-10-12" @default.
- W3029900321 title "Clinical experience in treatment of primary tracheal adenoid cystic carcinoma" @default.
- W3029900321 doi "https://doi.org/10.3877/cma.j.issn.2095-8773.2015.03.006" @default.
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