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- W3029915237 abstract "目的 与血清肌酐(SCr)、肌酐清除率(Ccr)比较,评价血清半胱氨酸蛋白酶抑制剂C(Cystatin C)在2型糖尿病患者肾小球滤过功能改变中的临床应用价值.方法以99mTc-DTPA清除率测得的肾小球滤过率(GFR)作为诊断评价的金指标,比较Cystatin C、Scr、Ccr与GFR的相关性,用受试者工作特征曲线(ROC)评价上述指标检测肾小球滤过功能的准确性.结果 51例患者血Cystatin C、Scr 及Ccr与99mTc-DTPA清除率相关系数分别为-0.744、-0.658、0.625 (P值均 < 0.001).3项指标ROC曲线下的面积(AUC)分别为0.891、0.77、0.753,且Cystatin C 与Ccr两者间的AUC差异有统计学意义(P<0.05 ).ROC曲线阈值移动发现血清Cystatin C判定肾小球滤过功能减退的最佳诊断界值(cut off值)为1.02 mg/L,此时诊断的灵敏度和特异性分别为 92.3 %、68.4 %,而以SCr参考值上限(133 μmol/L)和Ccr的参考值下限(80 ml/min)为cut off值,则不能同时得到理想的诊断灵敏度和特异性.结论 Cystatin C是一较理想的反映GFR血清标志物, 建议在常规检测SCr、Ccr的基础上,联合应用Cystatin C可更早地发现2型糖尿患者GFR的改变。" @default.
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- W3029915237 date "2005-06-21" @default.
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- W3029915237 title "Comparison of serum Cystatin C and creatinine in the detection of glomeruli filtration function in diabetic patients" @default.
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