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- W3029940929 abstract "目的 探讨移植肝缺血再灌注损伤程度的评估方法及其与肝移植患者预后的关系.方法 21 8例良性终末期肝病患者,在移植肝恢复血液灌注后1 h采取外周静脉血,测定丙氨酸转氨酶浓度(定义为基础肝功能),同时采用组织气体分析仪测定肝组织的氧分压,并取肝组织活检,计算水变性及坏死细胞百分比,分别对上述3项指标进行评分,再根据各指标得分之和将缺血-再灌注损伤程度划分为5级(0~Ⅳ级),统计围手术期(术后2周内)、术后近期(术后2周至1个月)、术后中远期(1个月以上)的患者死亡率.结果 移植肝缺血再灌注损伤程度评为0级者157例(A组),死亡7例(4.5%),71.4%(5/7)死于术后3~6个月;缺血-再灌注损伤程度评为Ⅰ级者25例(B组),死亡5例(20.0%),80.0%(4/5)死于术后2周至3个月;缺血-再灌注损伤程度评为Ⅱ级者23例(C组),死亡5例(21.7%),80.0%(4/5)死于术后2周至3个月;缺血-再灌注损伤程度评为Ⅲ级者8例(D组),死亡7例(87.5%),85.7%(6/7)死于术后1个月内;缺血-再灌注损伤程度评为Ⅳ级者5例(E组),全部死亡,80.0%(4/5)死于术后1个月内.A组各期死亡率明显低于B组、C组(P<0.05)和D组、E组(P<0.01);B组、C组间各期死亡率的差异无统计学意义(P>0.05);B组、C组各期死亡率均低于D组、E组(P<0.05).结论 基础肝功能、组织氧分压以及水变性和坏死细胞百分比三项指标可基本反映移植肝缺血-再灌注损伤程度;缺血-再灌注损伤评级达Ⅲ~Ⅳ级者术后死亡率较高。" @default.
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- W3029940929 date "2006-11-20" @default.
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- W3029940929 title "Evaluation of ischemia-reperfusion injury of liver grafts and its impact upon the prognosis of patients after liver transplantation" @default.
- W3029940929 doi "https://doi.org/10.3760/cma.j.issn.0254-1785.2006.11.007" @default.
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