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- W3029977054 abstract "Objective To study the effects of peroxisome prolifterator-activated receptor gamma (PPARγ) agonist on the apoptosis in the ischemia-reperfusion brain tissues and to study its mechanisms which has the correlation with NO. Methods Adult male SD rats were randomly divided into four groups: sham-operation+normal saline (NS),ischemia-reperfusion ( I/R) +NS,I/R+ low-dose Pioglitazone (PGZ,PPARγ agonists,10 mg/kg,once daily),and I/R+high-dose PGZ (15 mg/kg,once daily).The mode of transient middle cerebral artery occulision was made by using the suture of Longa. By intragastric administration,all rats were given NS and/or PGZ daily for 3 days. Before operation,apoptosis(by TUNEL),expression of iNOS mRNA(by RT-PCR),activities of iNOS and the content of NO (by Spectrophotometry ) were measured at 24h after ischemia. Results The apoptosis(36.5±6.3),expression of iNOS mRNA(0.597±0.027),activities of iNOS(1.369±0.417)U/mg.protein, the content of NO (24.44±4.81)μmol/g.protein in the low-dose PGZ group and the apoptosis(24.6±4.2),expression of iNOSmRNA(0.381±0.022),activities of iNOS(0.722±0.295)U/mg.protein, the content of NO (24.44±4.81)μmol/g.protein of high-dose PGZ group were significantly reduced compared with that[apoptosis:47.7±6.9;expression of iNOS mRNA:0.827±0.038; activities of iNOS:(2.041±0.582)U/mg.protein; the content of NO:(52.63±5.97)μmol/g protein] of the I/R+NS group( P <0.05).The downregulation degree increased along with the dosage of Pioglitazone,there were significant differences between low-dose PGZ group and high-dose PGZ group( P <0.05).Conclusions PPARγ agonists can reduce the generation of NO to resist nerve cells apoptosis by downregulate expression and activities of iNOS mRNA,and it may be one of the mechanisms in the protective action of PPARγ on ischemia-reperfusion injury.Key words: Peroxisome prolifterator-activated receptor γ; Pioglitazone; Apoptosis" @default.
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- W3029977054 date "2009-04-20" @default.
- W3029977054 modified "2023-09-27" @default.
- W3029977054 title "Effects of peroxisome prolifterator-activated receptor gamma (PPARγ) agonist on the apoptosis in the ischemia-reperfusion brain tissues and its mechanisms with NO" @default.
- W3029977054 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2009.04.006" @default.
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